Evidence map›Paper›PMID 28596679›Full record

ArticleWorld journal of gastroenterology2017

Oxidative stress-induced mitochondrial dysfunction in a normal colon epithelial cell line.

Nandakumar Packiriswamy, Kari F Coulson, Susan J Holcombe, Lorraine M Sordillo

Open access · hybridAbstract read
In one paragraph

Article in World journal of gastroenterology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 19 citations in OpenAlex.

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  5. Cyclotrisiloxan and β-Sitosterol richSaudi journal of biological sciences · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Nandakumar PackiriswamyNandakumar Packiriswamy, Kari F Coulson, Susan J Holcombe, Lorraine M Sordillo, Department of Large Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, MI 48824, United States.
Kari F CoulsonNandakumar Packiriswamy, Kari F Coulson, Susan J Holcombe, Lorraine M Sordillo, Department of Large Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, MI 48824, United States.
Susan J HolcombeNandakumar Packiriswamy, Kari F Coulson, Susan J Holcombe, Lorraine M Sordillo, Department of Large Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, MI 48824, United States.
Lorraine M SordilloNandakumar Packiriswamy, Kari F Coulson, Susan J Holcombe, Lorraine M Sordillo, Department of Large Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, MI 48824, United States.
Michigan State University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo determine how a normal human colon cell line reacts to microbial challenge as a way to study oxidative stress-induced responses associated with inflammatory bowel disease.

methodsNormal human colon epithelial cells (ATCC

resultsExposing CRL.1790 cells to microbial challenge stimulated cells to produce several relevant biomarkers associated with inflammation and oxidative stress. Heat killed cecal contents treatment induced a 10-12 fold increase in IL-8 production by CRL.1790 cells compared to unstimulated controls at 6 and 12 h (

conclusionThe findings from this study suggest that CRL.1790 cells may be a useful alternative to other colon cancer cell lines in studying the mechanisms of oxidative stress events associated with intestinal inflammatory disorders.

Indexed as

Oxidative StressAnimalsAutophagyBiomarkersCecumCell LineCell Line, TumorChemokinesColonCytokinesEpithelial CellsEscherichia coliHot TemperatureHumansInflammationInflammatory Bowel DiseasesBiomarkersChemokinesCytokinesReactive Oxygen SpeciesAutophagyColon cancer cell lineCRL.1790 cellsInflammationInterleukin-8Microbial stimulationMitochondria

Identifiers

PMID28596679
PMCPMC5442079
OpenAlexW2616330075

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.