ArticleScientific reports2017
Sequence variant at 4q25 near PITX2 associates with appendicitis.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.
- Pooled it
- The impact of pediatric constipation on appendicitis: a prospective birth cohort in the Japan Environment and Children's Study.BMC pediatrics · 2025Article
- Appendicitis.Nature reviews. Disease primers · 2025Review
- Investigation of VGLL3 and sub-target genes in the aetiology of paediatric acute appendicitis: a prospective case-control study.Pediatric surgery international · 2023Article
- Elemental, fatty acid, and protein composition of appendicoliths.Scientific reports · 2022Article
- Distribution of RET proto-oncogene variants in children with appendicitis.Molecular genetics & genomic medicine · 2022Article
- Larger Physique as a Risk Factor for Infantile Appendicitis: A Retrospective Study.Pediatric reports · 2022Article
- Impact of Human Genetic Variation on C-Reactive Protein Concentrations and Acute Appendicitis.Frontiers in immunology · 2022Article
- Simultaneous acute appendicitis in identical twin boys.BMJ case reports · 2019Article
- Next-Generation Sequencing Strategies.Cold Spring Harbor perspectives in medicine · 2019Review
- Genetic association and differential expression of PITX2 with acute appendicitis.Human genetics · 2019Article
Corrections and comments
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Authors and funding
25 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Appendicitis is one of the most common conditions requiring acute surgery and can pose a threat to the lives of affected individuals. We performed a genome-wide association study of appendicitis in 7,276 Icelandic and 1,139 Dutch cases and large groups of controls. In a combined analysis of the Icelandic and Dutch data, we detected a single signal represented by an intergenic variant rs2129979 [G] close to the gene PITX2 associating with increased risk of appendicitis (OR = 1.15, P = 1.8 × 10
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Registered trials
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