ArticleScientific reports2017
An Alcaligenes strain emulates Bacillus thuringiensis producing a binary protein that kills corn rootworm through a mechanism similar to Cry34Ab1/Cry35Ab1.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Vip3C proteins fromApplied and environmental microbiology · 2025Article
- An aegerolysin-like protein from Heliothis virescens ascovirus 3h (HvAV-3h) shows immune suppression and antibacterial activity.The Journal of general virology · 2025Article
- Advances in research and utilization of botanical pesticides for agricultural pest management in Inner Mongolia, China.Chinese herbal medicines · 2024Review
- IPD072Aa from Pseudomonas chlororaphis Targets Midgut Epithelial Cells in Killing Western Corn Rootworm (Applied and environmental microbiology · 2023Article
- Interaction of insecticidal proteins from Pseudomonas spp. and Bacillus thuringiensis for boll weevil management.PloS one · 2023Article
- Chromobacterium Csp_P biopesticide is toxic to larvae of three Diabrotica species including strains resistant to Bacillus thuringiensis.Scientific reports · 2022Article
- Towards Understanding the Function of Aegerolysins.Toxins · 2022Review
- Isolation of Bacterial and Fungal Microbiota Associated withMicroorganisms · 2022Article
- Lipid-Binding Aegerolysin from Biocontrol FungusToxins · 2021Article
- Article
- Crystal structure of RahU, an aegerolysin protein from the human pathogen Pseudomonas aeruginosa, and its interaction with membrane ceramide phosphorylethanolamine.Scientific reports · 2021Article
- Western Corn Rootworm, Plant and Microbe Interactions: A Review and Prospects for New Management Tools.Insects · 2021Review
- A high-resolution (1.2 Å) crystal structure of the anti-CRISPR protein AcrIF9.FEBS open bio · 2020Article
- Article
- Article
- Pore-forming protein complexes from Pleurotus mushrooms kill western corn rootworm and Colorado potato beetle through targeting membrane ceramide phosphoethanolamine.Scientific reports · 2019Article
- Susceptible and mCry3A resistant corn rootworm larvae killed by a non-hemolytic Bacillus thuringiensis Cyt1Aa mutant.Scientific reports · 2018Article
- Piercing Fishes: Porin Expansion and Adaptation to Hematophagy in the Vampire Snail Cumia reticulata.Molecular biology and evolution · 2018Article
- A selective insecticidal protein from Pseudomonas mosselii for corn rootworm control.Plant biotechnology journal · 2018Article
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17 authors.
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Abstract
Crops expressing Bacillus thuringiensis (Bt)-derived insecticidal protein genes have been commercially available for over 15 years and are providing significant value to growers. However, there remains the need for alternative insecticidal actives due to emerging insect resistance to certain Bt proteins. A screen of bacterial strains led to the discovery of a two-component insecticidal protein named AfIP-1A/1B from an Alcaligenes faecalis strain. This protein shows selectivity against coleopteran insects including western corn rootworm (WCR). Transgenic maize plants expressing AfIP-1A/1B demonstrate strong protection from rootworm injury. Surprisingly, although little sequence similarity exists to known insecticidal proteins, efficacy tests using WCR populations resistant to two different Cry proteins show that AfIP-1A/1B and mCry3A differ in their mode of action while AfIP-1A/1B and the binary Cry34Ab1/Cry35Ab1 protein share a similar mode. These findings are supported by results of competitive binding assays and the similarity of the x-ray structure of AfIP-1A to Cry34Ab1. Our work indicates that insecticidal proteins obtained from a non-Bt bacterial source can be useful for developing genetically modified crops and can function similarly to familiar proteins from Bt.
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