ArticleScientific reports2017
Recombinant human plasma phospholipid transfer protein (PLTP) to prevent bacterial growth and to treat sepsis.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 35 citations in OpenAlex.
- Endotoxemia and its association with immune and coagulopathy responses in severe community-acquired pneumonia and COVID-19.Intensive care medicine experimental · 2026Article
- High-density lipoproteins alleviate the endotoxin burden in patients with peritonitis and sepsis: The LIPS study.European journal of clinical investigation · 2025Observational
- The role of phospholipid transfer protein in sepsis-associated acute kidney injury.Critical care (London, England) · 2025Observational
- Risk factors and prognostic value of endotoxemia in patients with acute myocardial infarction.Frontiers in cardiovascular medicine · 2024Article
- Phospholipid transfer protein ameliorates sepsis-induced cardiac dysfunction through NLRP3 inflammasome inhibition.Open medicine (Warsaw, Poland) · 2024Article
- Endotoxemia in Acute Heart Failure and Cardiogenic Shock: Evidence, Mechanisms and Therapeutic Options.Journal of clinical medicine · 2023Review
- Cytokine dysregulation despite immunoglobulin replacement therapy in common variable immunodeficiency (CVID).Frontiers in immunology · 2023Article
- Increased Weight Gain and Insulin Resistance in HF-Fed PLTP Deficient Mice Is Related to Altered Inflammatory Response and Plasma Transport of Gut-Derived LPS.International journal of molecular sciences · 2022Article
- Impact of High-Density Lipoproteins on Sepsis.International journal of molecular sciences · 2022Review
- Alterations of HDL's to piHDL's Proteome in Patients with Chronic Inflammatory Diseases, and HDL-Targeted Therapies.Pharmaceuticals (Basel, Switzerland) · 2022Review
- High-density lipoprotein infusion protects from acute graft-versus-host disease in experimental allogeneic hematopoietic cell transplantation.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2022Article
- Lipid and Lipoprotein Dysregulation in Sepsis: Clinical and Mechanistic Insights into Chronic Critical Illness.Journal of clinical medicine · 2021Review
- Endotoxin Mass Concentration in Plasma Is Associated With Mortality in a Multicentric Cohort of Peritonitis-Induced Shock.Frontiers in medicine · 2021Article
- Intra-Abdominal Lipopolysaccharide Clearance and Inactivation in Peritonitis: Key Roles for Lipoproteins and the Phospholipid Transfer Protein.Frontiers in immunology · 2021Article
- Increased Phospholipid Transfer Protein Activity Is Associated With Markers of Enhanced Lipopolysaccharide Clearance in Human During Cardiopulmonary Bypass.Frontiers in cardiovascular medicine · 2021Article
- Impact of Sepsis on High-Density Lipoprotein Metabolism.Frontiers in cell and developmental biology · 2021Article
- LDL apheresis as an alternate method for plasma LPS purification in healthy volunteers and dyslipidemic and septic patients.Journal of lipid research · 2020Article
- Inhibition of mitophagy drives macrophage activation and antibacterial defense during sepsis.The Journal of clinical investigation · 2020Article
- Article
- Modified lipoproteins in periodontitis: a link to cardiovascular disease?Bioscience reports · 2019Article
Corrections and comments
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Authors and funding
20 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although plasma phospholipid transfer protein (PLTP) has been mainly studied in the context of atherosclerosis, it shares homology with proteins involved in innate immunity. Here, we produced active recombinant human PLTP (rhPLTP) in the milk of new lines of transgenic rabbits. We successfully used rhPLTP as an exogenous therapeutic protein to treat endotoxemia and sepsis. In mouse models with injections of purified lipopolysaccharides or with polymicrobial infection, we demonstrated that rhPLTP prevented bacterial growth and detoxified LPS. In further support of the antimicrobial effect of PLTP, PLTP-knocked out mice were found to be less able than wild-type mice to fight against sepsis. To our knowledge, the production of rhPLTP to counter infection and to reduce endotoxemia and its harmful consequences is reported here for the first time. This paves the way for a novel strategy to satisfy long-felt, but unmet needs to prevent and treat sepsis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.