Trial reportJournal of applied physiology (Bethesda, Md. : 1985)2017
Dietary nitrate restores compensatory vasodilation and exercise capacity in response to a compromise in oxygen delivery in the noncompensator phenotype.
Trial report in Journal of applied physiology (Bethesda, Md. : 1985), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 20 citations in OpenAlex.
- Inorganic nitrate supplementation and blood flow restricted exercise tolerance in post-menopausal women.Nitric oxide : biology and chemistry · 2022Trial
- On the implication of dietary nitrate supplementation for the hemodynamic and fatigue response to cycling exercise.Journal of applied physiology (Bethesda, Md. : 1985) · 2021Trial
- Effect of Nitrate Supplementation on Delayed Onset Muscle Soreness Indices: A Double-Blind, Randomized, Cross-Over Clinical Trial.Medical journal of the Islamic Republic of Iran · 2026Article
- Leg blood flow and cardiac output are cyclically reduced during low-intensity exercise with intermittent KAATSU cuff inflation in young adults.Physiological reports · 2025Article
- Review
- Improved Effect of Spinach Extract on Physical Performance: A Systematic Review of Randomized Controlled Trials.Cureus · 2025Review
- Beetroot as a functional food with huge health benefits: Antioxidant, antitumor, physical function, and chronic metabolomics activity.Food science & nutrition · 2021Review
- Dietary nitrate and population health: a narrative review of the translational potential of existing laboratory studies.BMC sports science, medicine & rehabilitation · 2021Review
- Kinetic differences between macro- and microvascular measures of reactive hyperemia.Journal of applied physiology (Bethesda, Md. : 1985) · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recently, dietary nitrate supplementation has been shown to improve exercise capacity in healthy individuals through a potential nitrate-nitrite-nitric oxide pathway. Nitric oxide has been shown to play an important role in compensatory vasodilation during exercise under hypoperfusion. Previously, we established that certain individuals lack a vasodilation response when perfusion pressure reductions compromise exercising muscle blood flow. Whether this lack of compensatory vasodilation in healthy, young individuals can be restored with dietary nitrate supplementation is unknown. Six healthy (21 ± 2 yr), recreationally active men completed a rhythmic forearm exercise. During steady-state exercise, the exercising arm was rapidly transitioned from an uncompromised (below heart) to a compromised (above heart) position, resulting in a reduction in local pressure of -31 ± 1 mmHg. Exercise was completed following 5 days of nitrate-rich (70 ml, 0.4 g nitrate) and nitrate-depleted (70 ml, ~0 g nitrate) beetroot juice consumption. Forearm blood flow (in milliliters per minute; brachial artery Doppler and echo ultrasound), mean arterial blood pressure (in millimeters of mercury; finger photoplethysmography), exercising forearm venous effluent (ante-cubital vein catheter), and plasma nitrite concentrations (chemiluminescence) revealed two distinct vasodilatory responses: nitrate supplementation increased (plasma nitrite) compared with placebo (245 ± 60 vs. 39 ± 9 nmol/l;
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.