ArticleJournal of neurology, neurosurgery, and psychiatry2017
Examining the language and behavioural profile in FTD and ALS-FTD.
Article in Journal of neurology, neurosurgery, and psychiatry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
39 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Speech and language impairments in behavioral variant frontotemporal dementia: A systematic review.Neuroscience and biobehavioral reviews · 2021Pooled it
- The Study of Language in the Amyotrophic Lateral Sclerosis - Frontotemporal Spectrum Disorder: a Systematic Review of Findings and New Perspectives.Neuropsychology review · 2018Pooled it
- Language impairments in behavioural variant frontotemporal dementia: a comparative study with semantic dementia.Journal of neurology · 2026Article
- Rethinking anomia across the frontotemporal dementia spectrum: marker of language dysfunction or global cognitive decline?medRxiv : the preprint server for health sciences · 2026Article
- Somatic mosaicism in ALS and FTD identifies focal mutations associated with widespread degeneration.Nature genetics · 2026Article
- Exploring the PLD1-tau interaction in Frontotemporal Dementia.bioRxiv : the preprint server for biology · 2026Article
- Dysregulated neuronal mRNA transport and translation in FTD/ALS.NPJ dementia · 2026Review
- The Dual Role of Extracellular Vesicles in Aging and Age-Related Diseases: Pathophysiology and Therapeutic Potential.International journal of nanomedicine · 2026Review
- Characteristics and Motivations of People With Amyotrophic Lateral Sclerosis Who Pursue Medical Aid in Dying in California.Neurology. Clinical practice · 2025Article
- Artificial Intelligence-Assisted Comparative Analysis of the Overlapping Molecular Pathophysiology of Alzheimer's Disease, Amyotrophic Lateral Sclerosis, and Frontotemporal Dementia.International journal of molecular sciences · 2024Article
- Immunity impacts cognitive deficits across neurological disorders.Journal of neurochemistry · 2024Review
- Review
- Neurocognitive correlates of semantic memory navigation in Parkinson's disease.NPJ Parkinson's disease · 2024Article
- A comprehensive review on frontotemporal dementia: its impact on language, speech and behavior.Dementia & neuropsychologia · 2024Review
- Speech and language markers of neurodegeneration: a call for global equity.Brain : a journal of neurology · 2023Review
- Neuropsychological impairment in amyotrophic lateral sclerosis-frontotemporal spectrum disorder.Nature reviews. Neurology · 2023Review
- Recent Advances in Extracellular Vesicles in Amyotrophic Lateral Sclerosis and Emergent Perspectives.Cells · 2023Review
- Language impairment in the genetic forms of behavioural variant frontotemporal dementia.Journal of neurology · 2023Article
- Mild behavioral impairment as a potential marker of predementia risk states in motor neuron diseases.European journal of neurology · 2023Article
- Distinct disease trajectories in frontotemporal dementia-motor neuron disease and behavioural variant frontotemporal dementia: A longitudinal study.European journal of neurology · 2022Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
backgroundA proportion of patients with behavioural variant frontotemporal dementia (bvFTD) develop amyotrophic lateral sclerosis (ALS). It is currently unknown whether the behavioural and cognitive syndrome in bvFTD with ALS (ALS-FTD) is indistinguishable from that of bvFTD alone.
methodsA retrospective cohort of 241 patients with clinical diagnoses of bvFTD (n=185) or ALS-FTD (n=56) was examined with respect to behavioural, cognitive and neuropsychiatric symptoms. Features were rated as present or absent based on information recorded from clinical interviews and detailed neuropsychological assessment.
resultsA number of behavioural and affective changes were reported more frequently in bvFTD than ALS-FTD: social disinhibition (p<0.001), inertia (p<0.001), loss of sympathy and empathy (p
conclusionsOur findings suggest differences between bvFTD and ALS-FTD. In particular, while changes in social behaviour are prominent in bvFTD alone, there may be a comparatively greater degree of language impairment in ALS-FTD. Prospective exploration of the pattern of differences between these groups will be essential. Identification of a distinct neuropsychological phenotype in ALS-FTD may have clinical implications for early diagnosis, disease management and care planning and theoretical implications for our understanding of the relationship between ALS and FTD.
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Registered trials
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