Evidence map›Paper›PMID 28596234›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2017

Cathepsin B as a potential cystatin M/E target in the mouse hair follicle.

Merel A W Oortveld, Ivonne M J J van Vlijmen-Willems, Ferry F J Kersten, Tsing Cheng, Martijn Verdoes, Piet E J van Erp, Sjef Verbeek, Thomas Reinheckel, Wiljan J A J Hendriks, Joost Schalkwijk and 1 more

Open access · hybridAbstract read
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Deficiency of the human cysteine protease inhibitor cystatin M/E causes hypotrichosis and dry skin.Genetics in medicine : official journal of the American College of Medical Genetics · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 2 countries.

Merel A W OortveldDepartment of Dermatology, Radboud Institute for Molecular Life Sciences, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands.
Ivonne M J J van Vlijmen-WillemsDepartment of Dermatology, Radboud Institute for Molecular Life Sciences, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands.
Ferry F J KerstenDepartment of Dermatology, Radboud Institute for Molecular Life Sciences, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands.
Tsing ChengDepartment of Dermatology, Radboud Institute for Molecular Life Sciences, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands.
Martijn VerdoesDepartment of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands.
Piet E J van ErpDepartment of Dermatology, Radboud Institute for Molecular Life Sciences, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands.
Sjef VerbeekDepartment of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands.
Thomas ReinheckelInstitute of Molecular Medicine and Cell Research, Albert-Ludwigs-University, Freiburg, Germany.
Wiljan J A J HendriksDepartment of Cell Biology, Radboud Institute for Molecular Life Sciences, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands.
Joost SchalkwijkDepartment of Dermatology, Radboud Institute for Molecular Life Sciences, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands; joost.schalkwijk@radboudumc.nl.
Patrick L J M ZeeuwenDepartment of Dermatology, Radboud Institute for Molecular Life Sciences, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands; patrick.zeeuwen@radboudumc.nl.
Radboud University Nijmegen · NLCellGenix (Germany) · DELeiden University Medical Center · NLRadboud Institute for Molecular Life Sciences · NLRadboud University Medical Center · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Deficiency of the cysteine protease inhibitor cystatin M/E (Cst6) in mice leads to disturbed epidermal cornification, impaired barrier function, and neonatal lethality. We report the rescue of the lethal skin phenotype of

Indexed as

AlopeciaAnimalsCathepsin BCathepsin LCell DifferentiationCells, CulturedCystatin MEpidermisHair FollicleHumansMiceSkinCathepsin BCathepsin LCst6 protein, mouseCystatin Mactivity-based probesalopeciacysteine protease inhibitorepidermisproteases

Identifiers

PMID28596234
PMCPMC5602906
OpenAlexW2621880026

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.