ArticleJournal of hepatology2017
Crosstalk between type II NKT cells and T cells leads to spontaneous chronic inflammatory liver disease.
Article in Journal of hepatology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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Who cites it
21 citing papers in PubMed, 29 citations in OpenAlex.
- Natural Killer T cells promote cholestatic liver disease independent of antigen presentation by cholangiocytes.Hepatology communications · 2026Article
- Revealing the pathogenesis of autoimmune hepatitis and research progress in drug discovery from hepatic immune cells and intercellular communication signaling mechanisms.Frontiers in immunology · 2026Review
- Uncovering cellular perturbations and key mediator communications in liver cancer using single-cell RNA sequencing.Frontiers in immunology · 2026Article
- NKT cells-a generalist in disease treatment and a new key to unlock immunotherapy.Immunotherapy · 2025Review
- Role of immune cell interactions in alcohol-associated liver diseases.Liver research (Beijing, China) · 2024Review
- Natural Killer T (NKT) Cells in Autoimmune Hepatitis: Current Evidence from Basic and Clinical Research.Cells · 2023Review
- The role of natural killer T cells in liver transplantation.Frontiers in cell and developmental biology · 2023Review
- Innate lymphocytes: Role in alcohol-induced immune dysfunction.Frontiers in immunology · 2022Review
- New insights into iNKT cells and their roles in liver diseases.Frontiers in immunology · 2022Review
- The imbalance of Th1/Th2 triggers an inflammatory response in chicken spleens after ammonia exposure.Poultry science · 2020Article
- Ammonia inhalation-induced inflammation and structural impairment in the bursa of fabricius and thymus of broilers through NF-κB signaling pathway.Environmental science and pollution research international · 2020Article
- Complementary approaches to study NKT cells in cancer.Methods in enzymology · 2020Article
- Protective Function of Novel Fungal Immunomodulatory Proteins Fip-lti1 and Fip-lti2 fromOxidative medicine and cellular longevity · 2019Article
- Inflammatory Phenotype of Intrahepatic Sulfatide-Reactive Type II NKT Cells in Humans With Autoimmune Hepatitis.Frontiers in immunology · 2019Article
- Pernicious anemia associated with cryptogenic cirrhosis: Two case reports and a literature review.Medicine · 2018Article
- CD1d-Restricted Type II NKT Cells Reactive With Endogenous Hydrophobic Peptides.Frontiers in immunology · 2018Review
- Effects of Acute Cold Stress After Long-Term Cold Stimulation on Antioxidant Status, Heat Shock Proteins, Inflammation and Immune Cytokines in Broiler Heart.Frontiers in physiology · 2018Article
- Complex Network of NKT Cell Subsets Controls Immune Homeostasis in Liver and Gut.Frontiers in immunology · 2018Review
- The Role of Invariant NKT in Autoimmune Liver Disease: Can Vitamin D Act as an Immunomodulator?Canadian journal of gastroenterology & hepatology · 2018Review
- The Role of CD1d and MR1 Restricted T Cells in the Liver.Frontiers in immunology · 2018Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
BACKGROUND &
aimNatural killer T (NKT) cells are CD1d-restricted innate-like T cells that modulate innate and adaptive immune responses. Unlike the well-characterized invariant/type I NKT cells, type II NKT cells with a diverse T cell receptor repertoire are poorly understood. This study defines the pathogenic role of type II NKT cells in the etiology of chronic liver inflammation.
methodsTransgenic mice with the Lck promoter directing CD1d overexpression on T cells in Jα18 wild-type (Lck-CD1dTgJα18
resultsLck-CD1dTgJα18
conclusionsOur data reveals enhanced crosstalk between type II NKT cells and conventional T cells, leading to a T
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.