Evidence map›Paper›PMID 28596037›Full record

ArticleEuropean journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V2017

Development and evaluation of an oral fast disintegrating anti-allergic film using hot-melt extrusion technology.

Manjeet B Pimparade, Anh Vo, Abhijeet S Maurya, Jungeun Bae, Joseph T Morott, Xin Feng, Dong Wuk Kim, Vijay I Kulkarni, Roshan Tiwari, K Vanaja and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Accelerated Oral Healing byMedicina (Kaunas, Lithuania) · 2023
    Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. Review
  14. Article
  15. 3D Printing of Drug Nanocrystals for Film Formulations.Molecules (Basel, Switzerland) · 2021
    Article
  16. Review
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Manjeet B PimparadeDepartment of Pharmaceutics & Drug Delivery, School of Pharmacy, The University of Mississippi, University, MS, USA.
Anh VoDepartment of Pharmaceutics & Drug Delivery, School of Pharmacy, The University of Mississippi, University, MS, USA.
Abhijeet S MauryaDepartment of Pharmaceutics & Drug Delivery, School of Pharmacy, The University of Mississippi, University, MS, USA.
Jungeun BaeDepartment of Pharmaceutics & Drug Delivery, School of Pharmacy, The University of Mississippi, University, MS, USA.
Joseph T MorottDepartment of Pharmaceutics & Drug Delivery, School of Pharmacy, The University of Mississippi, University, MS, USA.
Xin FengDepartment of Pharmaceutics & Drug Delivery, School of Pharmacy, The University of Mississippi, University, MS, USA.
Dong Wuk KimDepartment of Pharmaceutics & Drug Delivery, School of Pharmacy, The University of Mississippi, University, MS, USA.
Vijay I KulkarniDepartment of Pharmaceutics & Drug Delivery, School of Pharmacy, The University of Mississippi, University, MS, USA.
Roshan TiwariDepartment of Pharmaceutics & Drug Delivery, School of Pharmacy, The University of Mississippi, University, MS, USA.
K VanajaInstitute for Drug Delivery and Biomedical Research, Bangalore, India.
Reena MurthyInstitute for Drug Delivery and Biomedical Research, Bangalore, India.
H N ShivakumarInstitute for Drug Delivery and Biomedical Research, Bangalore, India.
D NeupaneDepartment of Physics, University of Memphis, Memphis, TN, USA.
S R MishraDepartment of Physics, University of Memphis, Memphis, TN, USA.
S N MurthyDepartment of Pharmaceutics & Drug Delivery, School of Pharmacy, The University of Mississippi, University, MS, USA.
Michael A RepkaDepartment of Pharmaceutics & Drug Delivery, School of Pharmacy, The University of Mississippi, University, MS, USA; Pii Center for Pharmaceutical Technology, The University of Mississippi, University, MS, USA. Electronic address: marepka@olemiss.edu.

Funding

Center of Research Excellence in Natural Products Neuroscience (CORE-NPN)P20GM104932 · NIGMS · UNIVERSITY OF MISSISSIPPI · PI MAJUMDAR, SOUMYAJIT · 2012 to 2016
$10.0M
NIGMS NIH HHS P20 GM104932
6 · The paper itself

Abstract

The main objective of this novel study was to develop chlorpheniramine maleate orally disintegrating films (ODF) using hot-melt extrusion technology and evaluate the characteristics of the formulation using in vitro and in vivo methods. Modified starch with glycerol was used as a polymer matrix for melt extrusion. Sweetening and saliva-simulating agents were incorporated to improve palatability and lower the disintegration time of film formulations. A standard screw configuration was applied, and the last zone of the barrel was opened to discharge water vapors, which helped to manufacture non-sticky, clear, and uniform films. The film formulations demonstrated rapid disintegration times (6-11s) and more than 95% dissolution in 5min. In addition, the films had characteristic mechanical properties that were helpful in handling and storage. An animal model was employed to determine the taste masking of melt-extruded films. The lead film formulation was subjected to a human panel for evaluation of extent of taste masking and disintegration.

Indexed as

Hot TemperatureAdministration, OralAdolescentAdultAnimalsAnti-Allergic AgentsChlorpheniramineDrug CarriersDrug Evaluation, PreclinicalFemaleHumansMaleRatsRats, Sprague-DawleySolubilityTaste PerceptionAnti-Allergic AgentsChlorpheniramineDrug CarriersChlorpheniramine maleateContinuous manufacturingHot-melt extrusionHuman panel taste evaluationModified starchOrally disintegrating filmPediatric and geriatricTaste-masking

Identifiers

PMID28596037
PMCPMC5581999

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.