Evidence map›Paper›PMID 28595945›Full record

ReviewProgress in neuro-psychopharmacology & biological psychiatry2018

Role of placebo effects in pain and neuropsychiatric disorders.

Annabelle M Belcher, Sergi Ferré, Pedro E Martinez, Luana Colloca

Open access · bronzeAbstract readReview
In one paragraph

Review in Progress in neuro-psychopharmacology & biological psychiatry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 22 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Fecal Microbiota Transplantation in Neurological Disorders.Frontiers in cellular and infection microbiology · 2020
    Review
  5. Article
  6. Placebo hypoalgesia: above and beyond expectancy and conditioning.Current opinion in behavioral sciences · 2019
    Article
  7. The Placebo Effect in Pain Therapies.Annual review of pharmacology and toxicology · 2019
    Review
  8. Review
  9. Placebos Without Deception: Outcomes, Mechanisms, and Ethics.International review of neurobiology · 2018
    Review
  10. Expectancy Modulation of Opioid Neurotransmission.International review of neurobiology · 2018
    Review
  11. Placebo Analgesia in Rodents: Current and Future Research.International review of neurobiology · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Annabelle M BelcherDepartment of Psychiatry, School of Medicine, University of Maryland, Baltimore, USA.
Sergi FerréNational Institute on Drug Abuse, National Institutes of Health, Bethesda, USA.
Pedro E MartinezNational Institute of Mental Health, National Institutes of Health, Bethesda, USA.
Luana CollocaDepartment of Psychiatry, School of Medicine, University of Maryland, Baltimore, USA; Department of Pain and Translational Symptom Science, School of Nursing, University of Maryland, Baltimore, USA; Department of Anesthesiology and Psychiatry, School of Medicine, University of Maryland, Baltimore, USA; Center to Advance Chronic Pain Research, University of Maryland, Baltimore, USA. Electronic address: colloca@son.umaryland.edu.
National Institutes of Health · USUniversity of Maryland, Baltimore · US

Funding

Chronic orofacial pain: genetics, cognitive-emotional factors, and endogenous modulatory systemsR01DE025946 · NIDCR · UNIVERSITY OF MARYLAND BALTIMORE · PI COLLOCA, LUANA · 2016 to 2019
$2.1M
NIDCR NIH HHS R01 DE025946
6 · The paper itself

Abstract

The placebo (and the nocebo) effect is a powerful determinant of health outcomes in clinical disease treatment and management. Efforts to completely eradicate placebo effects have shifted dynamically, as increasingly more researchers are tuned to the potentially beneficial effects of incorporating those uncontrollable placebo effects into clinical therapeutic strategies. In this review, we highlight the major findings from placebo research, elucidating the main neurobiological systems and candidate determinants of the placebo phenomenon, and illustrate a perspective that can effectively frame future research on the topic. Finally, we issue a call for increased research on the efficacy of therapeutic strategies that incorporate placebo "tools," and argue that clinical trials of the placebo response in neuropsychiatric diseases and disorders has important and far-reaching translational and clinical relevance.

Indexed as

Pain ManagementPlacebo EffectHumansMental DisordersPainExpectancyNocebo effectPharmacological and context-dependent conditioningSocial observationalVerbal suggestion

Identifiers

PMID28595945
PMCPMC5722709
OpenAlexW2663750889

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.