ArticleNeurotoxicology2018
The effect of manganese exposure in Atp13a2-deficient mice.
Open access · greenAbstract read
In one paragraph
Article in Neurotoxicology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 29 citations in OpenAlex.
- Progress in modelling ATP13A2-linked neurodegeneration.NPJ Parkinson's disease · 2026Review
- Phenotypic characterization of an Atp13a2 knockout rat model of Parkinson's disease.NPJ Parkinson's disease · 2025Article
- Phenotype Differences Between ATP13A2 Heterozygous and Knockout Mice Across Aging.International journal of molecular sciences · 2025Article
- Behavioral Alterations in Mice Exposed to Manganese via Drinking Water: Effects of Sex and a Lipopolysaccharide Challenge.Journal of applied toxicology : JAT · 2025Article
- Nigral ATP13A2 depletion induces Parkinson's disease-related neurodegeneration in a pilot study in non-human primates.NPJ Parkinson's disease · 2024Article
- Structures and coordination chemistry of transporters involved in manganese and iron homeostasis.Biochemical Society transactions · 2023Review
- ATP13A2 (PARK9) and basal ganglia function.Frontiers in neurology · 2023Review
- ATP13A2 Declines Zinc-Induced Accumulation of α-Synuclein in a Parkinson's Disease Model.International journal of molecular sciences · 2022Article
- ATP13A2 protects dopaminergic neurons in Parkinson's disease: from biology to pathology.Journal of biomedical research · 2022Article
- The Potential Roles of Blood-Brain Barrier and Blood-Cerebrospinal Fluid Barrier in Maintaining Brain Manganese Homeostasis.Nutrients · 2021Review
- Molecular Targets of Manganese-Induced Neurotoxicity: A Five-Year Update.International journal of molecular sciences · 2021Review
- The Role of Autophagy in Manganese-Induced Neurotoxicity.Frontiers in neuroscience · 2020Review
- Downregulation of ATP13A2 in midbrain dopaminergic neurons is related to defective autophagy in a mouse model of Parkinson's disease.International journal of clinical and experimental pathology · 2020Article
- Pharmacological inhibition of CSF1R by GW2580 reduces microglial proliferation and is protective against neuroinflammation and dopaminergic neurodegeneration.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020Article
- Role of Astrocytes in Manganese Neurotoxicity Revisited.Neurochemical research · 2019Review
- Complexity of Generating Mouse Models to Study the Upper Motor Neurons: Let Us Shift Focus from Mice to Neurons.International journal of molecular sciences · 2019Review
- Overexpression of human Atp13a2Isoform-1 protein protects cells against manganese and starvation-induced toxicity.PloS one · 2019Article
- Exacerbation of sensorimotor dysfunction in mice deficient in Atp13a2 and overexpressing human wildtype alpha-synuclein.Behavioural brain research · 2018Article
- Neurotoxicity of manganese: Indications for future research and public health intervention from the Manganese 2016 conference.Neurotoxicology · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 6 institutions in 1 country.
Sheila M FlemingDepartment of Pharmaceutical Sciences, Northeast Ohio Medical University, Rootstown, OH, United States. Electronic address: sfleming1@neomed.edu.
Nicholas A SantiagoDepartment of Pharmaceutical Sciences, Northeast Ohio Medical University, Rootstown, OH, United States.
Elizabeth J MullinDepartment of Chemistry, SUNY Buffalo, Buffalo, NY, United States.
Shanta PamphileDepartment of Neurology, University of Cincinnati, Cincinnati, OH, United States.
Swagata KarkareDepartment of Neurology, University of Cincinnati, Cincinnati, OH, United States.
Andrew LemkuhlDepartment of Neurology, University of Cincinnati, Cincinnati, OH, United States.
Osunde R EkhatorDepartment of Neurology, University of Cincinnati, Cincinnati, OH, United States.
Stephen C LinnDepartment of Biological Sciences, Northern Kentucky University, Highland Heights, KY, United States.
John G HoldenDepartment of Neurology, University of Cincinnati, Cincinnati, OH, United States.
Diana S AgaDepartment of Chemistry, SUNY Buffalo, Buffalo, NY, United States.
Jerome A RothDepartment of Pharmacology and Toxicology, SUNY Buffalo, Buffalo, NY, United States.
Benjamin LiouDivision of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States.
Ying SunDivision of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States.
Gary E ShullDepartment of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati, Cincinnati, OH, United States.
Patrick J SchultheisDepartment of Biological Sciences, Northern Kentucky University, Highland Heights, KY, United States.
University of Cincinnati · USCincinnati Children's Hospital Medical Center · USNortheast Ohio Medical University · USNorthern Kentucky University · USUniversity at Buffalo, State University of New York · USBuffalo State University · US
Funding
The interaction between ATP13A2 and alpha-synuclein in miceR21NS077022 · NINDS · UNIVERSITY OF CINCINNATI · PI FLEMING, SHEILA · 2011 to 2012
$432kBehavioral and Neuroanatomical Characterization of a Novel Genetic Animal Model oR15NS070268 · NINDS · NORTHERN KENTUCKY UNIVERSITY · PI SCHULTHEIS, PATRICK JOHN · 2010 to 2010
$203kNINDS NIH HHS R15 NS070268NINDS NIH HHS R21 NS077022
Abstract
Loss of function mutations in the P
Indexed as
Adenosine Triphosphatasesalpha-SynucleinAnimalsBehavior, AnimalBrainFemaleMaleManganeseMembrane ProteinsMice, Inbred C57BLMice, KnockoutMotor ActivityProton-Translocating ATPasesAdenosine Triphosphatasesalpha-SynucleinATP13A2 protein, mouseManganeseMembrane ProteinsProton-Translocating ATPasesAlpha-synucleinLipofuscinManganeseMiceParkinson’s diseaseSensorimotor function
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.