Trial reportJournal of the American College of Cardiology2017
Angiotensin-Converting Enzyme Inhibition Early After Heart Transplantation.
Trial report in Journal of the American College of Cardiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01078363 (ACE Inhibition and Cardiac Allograft Vasculopathy), which is not on this map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
ACE Inhibition and Cardiac Allograft Vasculopathy
Who cites it
21 citing papers in PubMed, 59 citations in OpenAlex.
- Trial
- COlchicine to Prevent PeriprocEdural Myocardial Injury in Percutaneous Coronary Intervention (COPE-PCI): Coronary Microvascular Physiology Pilot Substudy.Journal of interventional cardiology · 2022Trial
- 1-Year Outcomes of Angina Management Guided by Invasive Coronary Function Testing (CorMicA).JACC. Cardiovascular interventions · 2020 · on this mapTrial
- Mitigating Risk of Kidney Dysfunction After Heart Transplantation and Therapeutic Approaches.Circulation. Heart failure · 2026Review
- Association of vascular endothelial function and quality of life in patients with ischemia and non-obstructive coronary artery disease.Heart and vessels · 2023Observational
- Endothelial progenitor cells in the host defense response.Pharmacology & therapeutics · 2023Review
- In Vivo Validation of a Novel Computational Approach to Assess Microcirculatory Resistance Based on a Single Angiographic View.Journal of personalized medicine · 2022Article
- Small molecule angiotensin converting enzyme inhibitors: A medicinal chemistry perspective.Frontiers in pharmacology · 2022Review
- ARNI Pre-Operative Use and Vasoplegic Syndrome in Patients Undergoing Heart Transplantation or Left Ventricular Assist Device Surgery.Medical sciences (Basel, Switzerland) · 2021Article
- Prognostic value of comprehensive intracoronary physiology assessment early after heart transplantation.European heart journal · 2021Article
- The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: Thirty-eighth adult heart transplantation report - 2021; Focus on recipient characteristics.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2021Article
- Right ventricular hemodynamics and performance in relation to perfusion during first year after heart transplantation.ESC heart failure · 2021Article
- Review
- Hyperkalemia: Major but still understudied complication among heart transplant recipients.World journal of transplantation · 2021Review
- Assessment of late-term progression of cardiac allograft vasculopathy in patients with orthotopic heart transplantation using quantitative cardiacThe international journal of cardiovascular imaging · 2021Article
- Assessment of Vascular Dysfunction in Patients Without Obstructive Coronary Artery Disease: Why, How, and When.JACC. Cardiovascular interventions · 2020Review
- Angina: contemporary diagnosis and management.Heart (British Cardiac Society) · 2020Review
- Serial Assessment of Coronary Flow Reserve by Rubidium-82 Positron Emission Tomography Predicts Mortality in Heart Transplant Recipients.JACC. Cardiovascular imaging · 2020Observational
- Association of Endothelin-1 With Accelerated Cardiac Allograft Vasculopathy and Late Mortality Following Heart Transplantation.Journal of cardiac failure · 2019Article
- Longitudinal changes in kidney function following heart transplantation: Stanford experience.Clinical transplantation · 2018Article
Corrections and comments
- Commented on by
Authors and funding
17 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundCardiac allograft vasculopathy (CAV) remains a leading cause of mortality after heart transplantation (HT). Angiotensin-converting enzyme inhibitors (ACEIs) may retard the development of CAV but have not been well studied after HT.
objectivesThis study tested the safety and efficacy of the ACEI ramipril on the development of CAV early after HT.
methodsIn this prospective, multicenter, randomized, double-blind, placebo-controlled trial, 96 HT recipients were randomized to undergo ramipril or placebo therapy. They underwent coronary angiography, endothelial function testing; measurements of fractional flow reserve (FFR) and coronary flow reserve (CFR) and the index of microcirculatory resistance (IMR); and intravascular ultrasonography (IVUS) of the left anterior descending coronary artery, within 8 weeks of HT. At 1 year, the invasive assessment was repeated. Circulating endothelial progenitor cells (EPCs) were quantified at baseline and 1 year.
resultsPlaque volumes at 1 year were similar between the ramipril and placebo groups (162.1 ± 70.5 mm
conclusionsRamipril does not slow development of epicardial plaque volume but does stabilize levels of endothelial progenitor cells and improve microvascular function, which have been associated with improved long-term survival after HT. (Angiotensin Converting Enzyme [ACE] Inhibition and Cardiac Allograft Vasculopathy; NCT01078363).
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.