ArticleNucleic acids research2017
A mechanism for a single nucleotide intron shift.
Article in Nucleic acids research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 16 citations in OpenAlex.
- Propagation of [D1,2]-type spliceosomal twin introns (stwintrons) inMicrobiology spectrum · 2025Article
- An ascomycete H4 variant with an unknown function.Royal Society open science · 2024Article
- Bi-alignments with affine gaps costs.Algorithms for molecular biology : AMB · 2022Article
- Unique and Repeated Stwintrons (Spliceosomal Twin Introns) in the Hypoxylaceae.Journal of fungi (Basel, Switzerland) · 2022Article
- Internally Symmetrical Stwintrons and Related Canonical Introns in Hypoxylaceae Species.Journal of fungi (Basel, Switzerland) · 2021Article
- Is there any intron sliding in mammals?BMC evolutionary biology · 2020Article
- Phylogenetic Analyses of Glycosyl Hydrolase Family 6 Genes in Tunicates: Possible Horizontal Transfer.Genes · 2020Article
- Comprehensive genomic analyses with 115 plastomes from algae to seed plants: structure, gene contents, GC contents, and introns.Genes & genomics · 2020Article
- A functional twintron, 'zombie' twintrons and a hypermobile group II intron invading itself in plant mitochondria.Nucleic acids research · 2020Article
- A spliceosomal twin intron (stwintron) participates in both exon skipping and evolutionary exon loss.Scientific reports · 2019Article
- Emergence and loss of spliceosomal twin introns.Fungal biology and biotechnology · 2017Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Spliceosomal introns can occupy nearby rather than identical positions in orthologous genes (intron sliding or shifting). Stwintrons are complex intervening sequences, where an 'internal' intron interrupts one of the sequences essential for splicing, generating after its excision, a newly formed canonical intron defined as 'external'. In one experimentally demonstrated configuration, two alternatively excised internal introns, overlapping by one G, disrupt respectively the donor and the acceptor sequence of an external intron, leading to mRNAs encoding identical proteins. In a gene encoding a DHA1 antiporter in Pezizomycotina, we find a variety of predicted intron configurations interrupting the DNA stretch encoding a conserved peptidic sequence. Some sport a stwintron where the internal intron interrupts the donor of the external intron (experimentally confirmed for Aspergillus nidulans). In others, we found and demonstrate (for Trichoderma reesei) alternative, overlapping internal introns. Discordant canonical introns, one nt apart, are present in yet other species, exactly as predicted by the alternative loss of either of the internal introns at the DNA level from an alternatively spliced stwintron. An evolutionary pathway of 1 nt intron shift, involving an alternatively spliced stwintron intermediate is proposed on the basis of the experimental and genomic data presented.
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