ArticleChemical senses2017
Genetic Lineage Tracing in Taste Tissues Using Sox2-CreERT2 Strain.
Article in Chemical senses, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 30 citations in OpenAlex.
- Obesity-induced taste bud loss in mice is only partially remediated long after return to a healthy weight.International journal of obesity (2005) · 2026Article
- Developing and regenerating a sense of taste.Current topics in developmental biology · 2025Review
- The duct of von Ebner's glands is a source ofFrontiers in cell and developmental biology · 2024Article
- Give-and-take of gustation: the interplay between gustatory neurons and taste buds.Chemical senses · 2024Review
- EGR4 is critical for cell-fate determination and phenotypic maintenance of geniculate ganglion neurons underlying sweet and umami taste.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- SOX2-Sensing: Insights into the Role of SOX2 in the Generation of Sensory Cell Types in Vertebrates.International journal of molecular sciences · 2023Review
- Early Steps towards Hearing: Placodes and Sensory Development.International journal of molecular sciences · 2023Review
- Physiology of the tongue with emphasis on taste transduction.Physiological reviews · 2023Review
- A Transcription Factor Etv1/Er81 Is Involved in the Differentiation of Sweet, Umami, and Sodium Taste Cells.eNeuro · 2023Article
- Anterior and Posterior Tongue Regions and Taste Papillae: Distinct Roles and Regulatory Mechanisms with an Emphasis on Hedgehog Signaling and Antagonism.International journal of molecular sciences · 2023Review
- High Sox2 expression predicts taste lineage competency of lingual progenitors in vitro.Development (Cambridge, England) · 2023Article
- The sense of taste: Development, regeneration, and dysfunction.WIREs mechanisms of disease · 2022Review
- Neurosensory development of the four brainstem-projecting sensory systems and their integration in the telencephalon.Frontiers in neural circuits · 2022Article
- Article
- Characterization of normal and cancer stem-like cell populations in murine lingual epithelial organoids using single-cell RNA sequencing.Scientific reports · 2021Article
- Cellular Diversity and Regeneration in Taste Buds.Current opinion in physiology · 2021Article
- Expression of Eya1 in mouse taste buds.Cell and tissue research · 2021Article
- SARS-CoV-2 ReceptorACS pharmacology & translational science · 2020Article
- SOX2 regulates homeostasis of taste bud cells and lingual epithelial cells in posterior tongue.PloS one · 2020Article
- Three-Dimensional Imaging and Gene Expression Analysis Upon Enzymatic Isolation of the Tongue Epithelium.Frontiers in physiology · 2020Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
Taste cells in taste buds are epithelial sensory cells. Old taste bud cells die and are replaced by new ones generated from taste stem cells. Identifying and characterizing adult taste stem cells is therefore important to understand how peripheral taste tissues are maintained. SOX2 is expressed in oral epithelium including gustatory papillae and has been proposed to be a marker of adult taste stem/progenitor cells. Nevertheless, this hypothesis has never been directly tested. Here, by single-color genetic lineage tracing using Sox2-CreERT2 strain, we reveal that all types of taste bud cells distributed throughout the oral epithelium are derived from stem cells that express SOX2. Short-term tracing shows that SOX2-positive taste stem cells actively supply taste bud cells. At the base of epithelium outside taste buds are distributed proliferation marker- and SOX2-positive cells. Consistently, taste stem cells identified by Lgr5 expression in the circumvallate papillae also express SOX2. Together, taste stem cells distributed in oral epithelia express SOX2.
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