ArticleDementia and geriatric cognitive disorders2017
Neuropsychological Profiles Differentiate Alzheimer Disease from Subcortical Ischemic Vascular Dementia in an Autopsy-Defined Cohort.
Article in Dementia and geriatric cognitive disorders, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
What it found
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Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 51 citations in OpenAlex.
- Neuropsychological differential diagnosis of Alzheimer's disease and vascular dementia: a systematic review with meta-regressions.Frontiers in aging neuroscience · 2023Pooled it
- The clinical profile of cerebral small vessel disease: Toward an evidence-based identification of cognitive markers.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2023Pooled it
- Neuropsychological profile associated with financial exploitation vulnerability in older adults without dementia.The Clinical neuropsychologist · 2025Article
- Neuropsychiatric symptoms predict rate of change in executive function in Alzheimer's disease and related dementias.Journal of the International Neuropsychological Society : JINS · 2025Article
- Algorithm-defined memory impairment in older American Indians: The Strong Heart Study.Neuropsychology · 2024Article
- Classification Prediction of Alzheimer's Disease and Vascular Dementia Using Physiological Data and ECD SPECT Images.Diagnostics (Basel, Switzerland) · 2024Article
- Midlife Neuropsychological Profiles and Associated Vascular Risk: The Bogalusa Heart Study.Journal of Alzheimer's disease : JAD · 2023Article
- Correlation analysis between subtest scores of CERAD-K and a newly developed tablet computer-based digital cognitive test (Inbrain CST).Frontiers in aging neuroscience · 2023Article
- Brain-derived neurotrophic factor gene polymorphism affects cognitive function and neurofilament light chain level in patients with subcortical ischaemic vascular dementia.Frontiers in aging neuroscience · 2023Article
- Cognitive Profile of Large-Vessel Vascular Dementia-An Observational Study from a Tertiary Care Center in Kolkata.Journal of neurosciences in rural practice · 2022Article
- Vascular Cognitive Impairment and Dementia.Continuum (Minneapolis, Minn.) · 2022Review
- Article
- Brain energy failure in dementia syndromes: Opportunities and challenges for glucagon-like peptide-1 receptor agonists.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2022Review
- Sex is a defining feature of neuroimaging phenotypes in major brain disorders.Human brain mapping · 2022Review
- Distributed functional connectivity predicts neuropsychological test performance among older adults.Human brain mapping · 2021Article
- Discriminating subcortical ischemic vascular disease and Alzheimer's disease by diffusion kurtosis imaging in segregated thalamic regions.Human brain mapping · 2021Article
- The Analysis of Oxidative Stress Markers May Increase the Accuracy of the Differential Diagnosis of Alzheimer's Disease with and without Depression.Clinical interventions in aging · 2021Article
- Small Vessel Disease-Related Dementia: An Invalid Neurovascular Coupling?International journal of molecular sciences · 2020Review
- Lower retinal capillary density in minimal cognitive impairment among older Latinx adults.Alzheimer's & dementia (Amsterdam, Netherlands) · 2020Article
- B Vitamins and Fatty Acids: What Do They Share with Small Vessel Disease-Related Dementia?International journal of molecular sciences · 2019Review
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
Abstract
BACKGROUND/
aimsThe aim of this study was to assess the ability of neuropsychological tests to differentiate autopsy-defined Alzheimer disease (AD) from subcortical ischemic vascular dementia (SIVD).
methodsFrom a sample of 175 cases followed longitudinally that underwent autopsy, we selected 23 normal controls (NC), 20 SIVD, 69 AD, and 10 mixed cases of dementia. Baseline neuropsychological tests, including Memory Assessment Scale word list learning test, control oral word association test, and animal fluency, were compared between the three autopsy-defined groups.
resultsThe NC, SIVD, and AD groups did not differ by age or education. The SIVD and AD groups did not differ by the Global Clinical Dementia Rating Scale. Subjects with AD performed worse on delayed recall (p < 0.01). A receiver operating characteristics analysis comparing the SIVD and AD groups including age, education, difference between categorical (animals) versus phonemic fluency (letter F), and the first recall from the word learning test distinguished the two groups with a sensitivity of 85%, specificity of 67%, and positive likelihood ratio of 2.57 (AUC = 0.789, 95% CI 0.69-0.88, p < 0.0001).
conclusionIn neuropathologically defined subgroups, neuropsychological profiles have modest ability to distinguish patients with AD from those with SIVD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.