Evidence map›Paper›PMID 28595051›Full record

ReviewNeuron2017

Optimizing Neural Information Capacity through Discretization.

Tatyana O Sharpee

Abstract readReview
In one paragraph

Review in Neuron, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Tatyana O SharpeeThe Salk Institute for Biological Studies, Computational Neurobiology Laboratory, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA. Electronic address: sharpee@snl.salk.edu.

Funding

Core Grant for Vision ResearchP30EY019005 · NEI · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI ALBRIGHT, THOMAS D · 2009 to 2018
$7.7M
Neural mechanisms of shape perceptionR01EY019493 · NEI · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI SHARPEE, TATYANA O. · 2009 to 2013
$2.4M
NEI NIH HHS P30 EY019005NEI NIH HHS R01 EY019493
6 · The paper itself

Abstract

Discretization in neural circuits occurs on many levels, from the generation of action potentials and dendritic integration, to neuropeptide signaling and processing of signals from multiple neurons, to behavioral decisions. It is clear that discretization, when implemented properly, can convey many benefits. However, the optimal solutions depend on both the level of noise and how it impacts a particular computation. This Perspective discusses how current physiological data could potentially be integrated into one theoretical framework based on maximizing information. Key experiments for testing that framework are discussed.

Indexed as

Information TheoryModels, NeurologicalAction PotentialsBehaviorDecision MakingHumansNerve NetNeuronsNeuropeptidesNeuropeptidesdendritesinformation theoryion channelsionic currentsneural cell typesneuromodulationneuropeptidephase transitionspower lawscale-free dynamics

Identifiers

PMID28595051
PMCPMC5634811

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.