ArticleACS nano2017
Selective Targeting of Neurons with Inorganic Nanoparticles: Revealing the Crucial Role of Nanoparticle Surface Charge.
Article in ACS nano, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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Who cites it
49 citing papers in PubMed, 119 citations in OpenAlex.
- The Impact of Biomaterial Charge on Cells' Bioelectrical Signaling.Cells, tissues, organs · 2026Review
- Dual-Targeting Cuproptosis and Mitophagy via a Flavopiridol-Copper Nanoplatform Potentiates Immunotherapy Against Uveal Melanoma.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Tunable electrostatic interactions of lipid-coated quantum dots with biological membranes.bioRxiv : the preprint server for biology · 2026Article
- Delivery of monoclonal antibodies to the brain: the impact of nanocarrier structure.Drug delivery and translational research · 2026Article
- Regulation of Calcium Ion Channels with Conjugated Molecules for Modulating Biological Functions.ACS central science · 2025Review
- Transcranial and precise optical neuromodulation mediated by NIR photoactive nanosheets.Journal of nanobiotechnology · 2025Article
- Engineered Chitosan-Derived Nanocarrier for Efficient siRNA Delivery to Peripheral and Central Neurons.Advanced healthcare materials · 2025Article
- The Toxicological Profile of Active Pharmaceutical Ingredients-Containing Nanoparticles: Classification, Mechanistic Pathways, and Health Implications.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Multimodal Characterization of Cortical Neuron Response to Permanent Magnetic Field Induced Nanomagnetic Force Maps.ACS nano · 2024Article
- Numerical simulation study of nanoparticle diffusion in gray matter.Computational and structural biotechnology journal · 2024Article
- Nanomagnetic Guidance Shapes the Structure-Function Relationship of Developing Cortical Networks.Nano letters · 2024Article
- Development of a novel glucose-dendrimer based therapeutic targeting hyperexcitable neurons in neurological disorders.Bioengineering & translational medicine · 2024Article
- Photoacoustic: A Versatile Nongenetic Method for High-Precision Neuromodulation.Accounts of chemical research · 2024Review
- Augmenting insect olfaction performance through nano-neuromodulation.Nature nanotechnology · 2024Article
- Modified Carbon Nanotubes Favor Fibroblast Growth by Tuning the Cell Membrane Potential.ACS applied materials & interfaces · 2024Article
- Nano-delivery systems as a promising therapeutic potential for epilepsy: Current status and future perspectives.CNS neuroscience & therapeutics · 2023Review
- Neuronal maturation-dependent nano-neuro interaction and modulation.Nanoscale horizons · 2023Article
- Bacterial memory in antibiotic resistance evolution and nanotechnology in evolutionary biology.iScience · 2023Review
- Investigation of effects of transferrin-conjugated gold nanoparticles on hippocampal neuronal activity and anxiety behavior in mice.Molecular and cellular biochemistry · 2023Article
- Nonviral nanoparticle gene delivery into the CNS for neurological disorders and brain cancer applications.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology · 2023Review
Corrections and comments
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Authors and funding
15 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nanoparticles (NPs) are increasingly used in biomedical applications, but the factors that influence their interactions with living cells need to be elucidated. Here, we reveal the role of NP surface charge in determining their neuronal interactions and electrical responses. We discovered that negatively charged NPs administered at low concentration (10 nM) interact with the neuronal membrane and at the synaptic cleft, whereas positively and neutrally charged NPs never localize on neurons. This effect is shape and material independent. The presence of negatively charged NPs on neuronal cell membranes influences the excitability of neurons by causing an increase in the amplitude and frequency of spontaneous postsynaptic currents at the single cell level and an increase of both the spiking activity and synchronous firing at neural network level. The negatively charged NPs exclusively bind to excitable neuronal cells, and never to nonexcitable glial cells. This specific interaction was also confirmed by manipulating the electrophysiological activity of neuronal cells. Indeed, the interaction of negatively charged NPs with neurons is either promoted or hindered by pharmacological suppression or enhancement of the neuronal activity with tetrodotoxin or bicuculline, respectively. We further support our main experimental conclusions by using numerical simulations. This study demonstrates that negatively charged NPs modulate the excitability of neurons, revealing the potential use of NPs for controlling neuron activity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.