Evidence map›Paper›PMID 28594897›Full record

SynthesisPloS one2017

Prognostic value of long non-coding RNA CCAT1 expression in patients with cancer: A meta-analysis.

Deyao Shi, Fashuai Wu, Feng Gao, Xiangcheng Qing, Zengwu Shao

Expression of concernErratum issuedOpen access · goldAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It carries an expression of concern. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

  1. Pooled it
  2. LncRNAs in modulating cancer cell resistance to paclitaxel (PTX) therapy.Medical oncology (Northwood, London, England) · 2024
    Review
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. LncRNA & Wnt signaling in colorectal cancer.Cancer cell international · 2020
    Review
  12. Article
  13. Article
  14. To Wnt or Lose: The Missing Non-Coding Linc in Colorectal Cancer.International journal of molecular sciences · 2017
    Review
  15. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Deyao ShiOrthopaedic Hospital, Union Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, P.R. China.
Fashuai WuOrthopaedic Hospital, Union Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, P.R. China.
Feng GaoOrthopaedic Hospital, Union Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, P.R. China.
Xiangcheng QingOrthopaedic Hospital, Union Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, P.R. China.
Zengwu ShaoOrthopaedic Hospital, Union Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, P.R. China.ORCID http://orcid.org/0000-0002-2527-4097
Wuhan Union Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLncRNA CCAT1 is significantly overexpressed in various types of cancers, suggesting that it might be associated with prognosis and clinicopathological features in patients with cancer.

methodsA comprehensive search was performed in Pubmed, Web of Science, OVID and CNKI databases. We also retrieved articles from other sources, such as retrieving from the reference lists of relevant articles. Eligible studies were included based on defined exclusion and inclusion criteria to perform a meta-analysis. STATA 14.0 was used to estimate pooled hazard ratios (HRs) with 95% confidence interval (95% CI), the heterogeneity among studies and publication bias to judge the prognostic value.

resultsA total of 1587 patients from 11 eligible studies were included in the meta-analysis. The results showed that high expression level of CCAT1 was significantly associated with shorter overall survival in cancer patients (HR 2.335, 95% CI:1.551-3.517); in the subgroup analysis, region (China or UK), sample size (more or less than 100), type of cancer (digestive or non-digestive disease) and paper quality (score more or less than 7) did not alter the association between CCAT1 expression and cancer prognosis but preoperative treatment did. And CCAT1 expression was an independent prognostic marker for overall survival in patients with cancer (pooled HR 2.195, 95%CI:1.316-3.664) using Cox multivariate analyses. The clinicopathological parameters analysis further showed that increased expression level of CCAT1 was correlated with tumor size, lymph node metastasis, TNM stage, distant metastasis, microvascular invasion and capsular formation in relevant cancers.

conclusionsThe meta-analysis results from present study suggested that increased expression level of CCAT1 was associated with poor prognosis and can serve as an independent biomarker. And the expression level of CCAT1 was associated with clinicopathological features in relevant cancers.

Indexed as

Gene Expression Regulation, NeoplasticDisease-Free SurvivalGenetic Association StudiesHumansNeoplasm Recurrence, LocalNeoplasmsPrognosisProportional Hazards ModelsRNA, Long NoncodingSurvival AnalysisCCAT1 long noncoding RNA, humanRNA, Long Noncoding

Identifiers

PMID28594897
PMCPMC5464649
OpenAlexW2621479247

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.