ArticlePLoS computational biology2017
Temperature-amplitude coupling for stable biological rhythms at different temperatures.
Article in PLoS computational biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- A compartmentalized SCN model explains temperature resistance through interregional phase differences.PLoS computational biology · 2026Article
- Circadian rhythms remain temperature compensated during a Q neuron-induced hibernation-like state in mice.PLoS biology · 2026Article
- Intrinsic period stability of the cyanobacterial circadian oscillator across in vitro and in vivo conditions.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Temperature compensation of the Arabidopsis circadian clock.Npj biological timing and sleep · 2025Review
- Low temperature abolishes human cellular circadian rhythm through Hopf bifurcation.NPJ systems biology and applications · 2025Article
- Waveform distortion for temperature compensation and synchronization in circadian rhythms: An approach based on the renormalization group method.PLoS computational biology · 2025Article
- A Compensated Clock: Temperature and Nutritional Compensation Mechanisms Across Circadian Systems.BioEssays : news and reviews in molecular, cellular and developmental biology · 2025Review
- Frequency-modulated timer regulates torpor-arousal cycles during hibernation in distinct small mammalian hibernators.Npj biological timing and sleep · 2024Article
- The clock in growing hyphae and their synchronization in Neurospora crassa.Communications biology · 2024Article
- Temperature compensation through kinetic regulation in biochemical oscillators.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Alternative polyadenylation factor CPSF6 regulates temperature compensation of the mammalian circadian clock.PLoS biology · 2023Article
- Systematic analysis of negative and positive feedback loops for robustness and temperature compensation in circadian rhythms.NPJ systems biology and applications · 2023Article
- Artificial temperature-compensated biological clock using temperature-sensitive Belousov-Zhabotinsky gels.Scientific reports · 2022Article
- Insights about circadian clock in glioma: From molecular pathways to therapeutic drugs.CNS neuroscience & therapeutics · 2022Review
- Role of the reaction-structure coupling in temperature compensation of the KaiABC circadian rhythm.PLoS computational biology · 2022Article
- Article
- Development and Optimization of Expression, Purification, and ATPase Assay of KaiC for Medium-Throughput Screening of Circadian Clock Mutants in Cyanobacteria.International journal of molecular sciences · 2019Article
- Non-sinusoidal Waveform in Temperature-Compensated Circadian Oscillations.Biophysical journal · 2019Article
- Period-amplitude co-variation in biomolecular oscillators.IET systems biology · 2018Article
- Co-existing feedback loops generate tissue-specific circadian rhythms.Life science alliance · 2018Article
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5 authors.
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Abstract
Most biological processes accelerate with temperature, for example cell division. In contrast, the circadian rhythm period is robust to temperature fluctuation, termed temperature compensation. Temperature compensation is peculiar because a system-level property (i.e., the circadian period) is stable under varying temperature while individual components of the system (i.e., biochemical reactions) are usually temperature-sensitive. To understand the mechanism for period stability, we measured the time series of circadian clock transcripts in cultured C6 glioma cells. The amplitudes of Cry1 and Dbp circadian expression increased significantly with temperature. In contrast, other clock transcripts demonstrated no significant change in amplitude. To understand these experimental results, we analyzed mathematical models with different network topologies. It was found that the geometric mean amplitude of gene expression must increase to maintain a stable period with increasing temperatures and reaction speeds for all models studied. To investigate the generality of this temperature-amplitude coupling mechanism for period stability, we revisited data on the yeast metabolic cycle (YMC) period, which is also stable under temperature variation. We confirmed that the YMC amplitude increased at higher temperatures, suggesting temperature-amplitude coupling as a common mechanism shared by circadian and 4 h-metabolic rhythms.
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