Evidence map›Paper›PMID 28594278›Full record

Trial reportPharmacogenomics2017

Clinical and educational impact of pharmacogenomics testing: a case series from the INGENIOUS trial.

Rebecca C Pierson, Brandon T Gufford, Zeruesenay Desta, Michael T Eadon

Open access · greenAbstract readClinical Trial
In one paragraph

Trial report in Pharmacogenomics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 9 citations in OpenAlex.

  1. Trial
  2. Review
  3. Integrating pharmacogenetic testing into primary care.Expert review of precision medicine and drug development · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Rebecca C PiersonDepartment of Obstetrics, Gynecology & Women's Health, University of Louisville, KY 40202, USA.
Brandon T GuffordDepartment of Medicine, Division of Clinical Pharmacology, Indiana University, IN 46202, USA.
Zeruesenay DestaDepartment of Medicine, Division of Clinical Pharmacology, Indiana University, IN 46202, USA.
Michael T EadonDepartment of Medicine, Division of Clinical Pharmacology, Indiana University, IN 46202, USA.
Indiana University · USUniversity of Louisville · US

Funding

Indiana University Comprehensive Training in Clinical PharmacologyT32GM008425 · NIGMS · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI Zeruesenay Desta, Michael Thomas Eadon · 1992 to 2026
$7.7M
Embedding Pharmacogenotyping in an Integrated Health System for the UnderservedU01HG007762 · NHGRI · INDIANA UNIVERSITY INDIANAPOLIS · PI DEXTER, PAUL, SKAAR, TODD C. · 2014 to 2018
$4.4M
Acute inhibition of renal gene expression to prevent nephrotoxicity.K08DK107864 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI EADON, MICHAEL THOMAS · 2016 to 2020
$772k
NHGRI NIH HHS U01 HG007762NIDDK NIH HHS K08 DK107864NIGMS NIH HHS T32 GM008425
6 · The paper itself

Abstract

Pharmacogenomic testing has become increasingly widespread. However, there remains a need to bridge the gap between test results and providers lacking the expertise required to interpret these results. The Indiana Genomics Implementation trial is underway at our institution to examine total healthcare cost and patient outcomes after genotyping in a safety-net healthcare system. As part of the study, trial investigators and clinical pharmacology fellows interpret genotype results, review patient histories and medication lists and evaluate potential drug-drug interactions. We present a case series of patients in whom pharmacogenomic consultations aided providers in appropriately applying pharmacogenomic results within the clinical context. Formal consultations not only provide valuable patient care information but educational opportunities for the fellows to cement pharmacogenomic concepts.

Indexed as

AgedDelivery of Health CareDrug InteractionsFemaleGenotypeHealth Care CostsHumansMaleMiddle AgedPatient Education as TopicPharmacogeneticsPharmacogenomic Testingclinicaleducationgenetic testingpharmacogeneticspharmacologyprecision medicine

Identifiers

PMID28594278
PMCPMC5591461
OpenAlexW2623618091

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.