Evidence map›Paper›PMID 28594262›Full record

ArticleCell cycle (Georgetown, Tex.)2017

An analysis of gene expression data involving examination of signaling pathways activation reveals new insights into the mechanism of action of minoxidil topical foam in men with androgenetic alopecia.

Georgios N Stamatas, Jeff Wu, Apostolos Pappas, Paradi Mirmirani, Thomas S McCormick, Kevin D Cooper, Mary Consolo, Jane Schastnaya, Ivan V Ozerov, Alexander Aliper and 1 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell cycle (Georgetown, Tex.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 25 citations in OpenAlex.

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  8. Chemistry42: An AI-Driven Platform for Molecular Design and Optimization.Journal of chemical information and modeling · 2023
    Article
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  13. Female-pattern hair loss: therapeutic update.Anais brasileiros de dermatologia
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 2 countries.

Georgios N Stamatasa Emerging Science & Innovation, Johnson & Johnson Santé Beauté France , Johnson & Johnson Group of Consumer Companies , Issy-les-Moulineaux , France.ORCID http://orcid.org/0000-0003-4544-7597
Jeff Wub Hair Care R&D, Johnson & Johnson Consumer Worldwide , Johnson & Johnson Family of Consumer Companies, Inc. , Skillman , NJ , USA.
Apostolos Pappasc Emerging Science & Innovation, Johnson & Johnson Consumer Worldwide , Johnson & Johnson Family of Consumer Companies, Inc. , Skillman , NJ , USA.
Paradi Mirmiranid Department of Dermatology , The Permanente Medical Group , Vallejo , CA , USA.
Thomas S McCormickf Department of Dermatology , Case Western Reserve University, University Hospitals Cleveland Medical Center , Cleveland , OH , USA.
Kevin D Cooperf Department of Dermatology , Case Western Reserve University, University Hospitals Cleveland Medical Center , Cleveland , OH , USA.
Mary Consolof Department of Dermatology , Case Western Reserve University, University Hospitals Cleveland Medical Center , Cleveland , OH , USA.ORCID http://orcid.org/0000-0002-9095-5913
Jane Schastnayag Insilico Medicine, Inc., Emerging Technology Centers , Johns Hopkins University at Eastern , Baltimore , MD , USA.
Ivan V Ozerovg Insilico Medicine, Inc., Emerging Technology Centers , Johns Hopkins University at Eastern , Baltimore , MD , USA.
Alexander Aliperg Insilico Medicine, Inc., Emerging Technology Centers , Johns Hopkins University at Eastern , Baltimore , MD , USA.
Alex Zhavoronkovg Insilico Medicine, Inc., Emerging Technology Centers , Johns Hopkins University at Eastern , Baltimore , MD , USA.
Johns Hopkins University · USUniversity Hospitals of Cleveland · USJohnson & Johnson (United States) · USJohnson & Johnson (France) · FRUniversity of California, San Francisco · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Androgenetic alopecia is the most common form of hair loss. Minoxidil has been approved for the treatment of hair loss, however its mechanism of action is still not fully clarified. In this study, we aimed to elucidate the effects of 5% minoxidil topical foam on gene expression and activation of signaling pathways in vertex and frontal scalp of men with androgenetic alopecia. We identified regional variations in gene expression and perturbed signaling pathways using in silico Pathway Activation Network Decomposition Analysis (iPANDA) before and after treatment with minoxidil. Vertex and frontal scalp of patients showed a generally similar response to minoxidil. Both scalp regions showed upregulation of genes that encode keratin associated proteins and downregulation of ILK, Akt, and MAPK signaling pathways after minoxidil treatment. Our results provide new insights into the mechanism of action of minoxidil topical foam in men with androgenetic alopecia.

Indexed as

Gene Expression RegulationAdministration, TopicalAdolescentAdultAlopeciaGene Expression ProfilingHumansMaleMiddle AgedMinoxidilScalpSignal TransductionYoung AdultMinoxidilandrogenetic alopeciagene expressionhair lossminoxidilsignaling pathways

Identifiers

PMID28594262
PMCPMC5587030
OpenAlexW2621952159

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.