ArticleNature communications2017
Loss of Asxl2 leads to myeloid malignancies in mice.
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Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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21citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
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Who cites it
21 citing papers in PubMed, 30 citations in OpenAlex.
- The Mutational Landscape of Acute Myeloid Leukemia and Its Impact.International journal of molecular sciences · 2026Review
- Review
- Clinical Variability of Shashi-Pena Syndrome: A NovelMolecular syndromology · 2025Article
- Integrative analysis of ASXL family genes reveals ASXL2 as an immunoregulatory molecule in head and neck squamous cell carcinoma.Scientific reports · 2024Article
- Additional Sex Combs-like Family Associated with Epigenetic Regulation.International journal of molecular sciences · 2024Review
- Prognosis and risk factors for ASXL1 mutations in patients with newly diagnosed acute myeloid leukemia and myelodysplastic syndrome.Cancer medicine · 2024Article
- Identification of a de novo variant in the ASXL2 gene related to Shashi-Pena syndrome.Molecular genetics & genomic medicine · 2023Article
- A newborn with a pathogenic variant in ASXL2 expanding the phenotype of SHAPNS: a case report and literature review.Translational pediatrics · 2023Article
- Predicting leukemic transformation in myelodysplastic syndrome using a transcriptomic signature.Frontiers in genetics · 2023Article
- Role of ASXL1 in hematopoiesis and myeloid diseases.Experimental hematology · 2022Review
- ASXL1/2 mutations and myeloid malignancies.Journal of hematology & oncology · 2022Review
- Review
- Understanding the phenotypic spectrum of ASXL-related disease: Ten cases and a review of the literature.American journal of medical genetics. Part A · 2021Article
- HOXBLINC long non-coding RNA activation promotes leukemogenesis in NPM1-mutant acute myeloid leukemia.Nature communications · 2021Article
- Identification of Candidate Biomarker ASXL2 and Its Predictive Value in Pancreatic Carcinoma.Frontiers in oncology · 2021Article
- Myeloid-specific Asxl2 deletion limits diet-induced obesity by regulating energy expenditure.The Journal of clinical investigation · 2020Article
- The role of ASXL1 in hematopoiesis and myeloid malignancies.Cellular and molecular life sciences : CMLS · 2019Review
- Chromatin regulator Asxl1 loss and Nf1 haploinsufficiency cooperate to accelerate myeloid malignancy.The Journal of clinical investigation · 2018Article
- ASXL2 regulates hematopoiesis in mice and its deficiency promotes myeloid expansion.Haematologica · 2018Article
- Transcriptome-wide analysis uncovers the targets of the RNA-binding protein MSI2 and effects of MSI2's RNA-binding activity on IL-6 signaling.The Journal of biological chemistry · 2018Article
Corrections and comments
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Authors and funding
23 authors at 4 institutions in 2 countries.
Jianping LiSylvester Comprehensive Cancer Center, Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, 1011 NW 15th Street, Room 417, Miami, Florida 33136, USA.
Fuhong HeKey Laboratory of Genomic and Precision Medicine, Collaborative Innovation Center of Genetics and Development, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China.ORCID 0000-0002-3176-8309
Peng ZhangSylvester Comprehensive Cancer Center, Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, 1011 NW 15th Street, Room 417, Miami, Florida 33136, USA.
Shi ChenSylvester Comprehensive Cancer Center, Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, 1011 NW 15th Street, Room 417, Miami, Florida 33136, USA.
Hui ShiSylvester Comprehensive Cancer Center, Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, 1011 NW 15th Street, Room 417, Miami, Florida 33136, USA.
Yanling SunKey Laboratory of Genomic and Precision Medicine, Collaborative Innovation Center of Genetics and Development, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China.
Ying GuoSylvester Comprehensive Cancer Center, Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, 1011 NW 15th Street, Room 417, Miami, Florida 33136, USA.
Hui YangSylvester Comprehensive Cancer Center, Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, 1011 NW 15th Street, Room 417, Miami, Florida 33136, USA.
Na ManSylvester Comprehensive Cancer Center, Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, 1011 NW 15th Street, Room 417, Miami, Florida 33136, USA.
Sarah GreenblattSylvester Comprehensive Cancer Center, Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, 1011 NW 15th Street, Room 417, Miami, Florida 33136, USA.
Zhaomin LiSylvester Comprehensive Cancer Center, Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, 1011 NW 15th Street, Room 417, Miami, Florida 33136, USA.
Zhengyu GuoDepartment of Electrical and Computer Engineering, and TEES-AgriLife Center for Bioinformatics and Genomic Systems Engineering, Texas A&M University, College Station, Texas 77843, USA.
Yuan ZhouState Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300020, China.
Lan WangSylvester Comprehensive Cancer Center, Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, 1011 NW 15th Street, Room 417, Miami, Florida 33136, USA.
Lluis MoreySylvester Comprehensive Cancer Center, Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, 1011 NW 15th Street, Room 417, Miami, Florida 33136, USA.
Sion WilliamsSylvester Comprehensive Cancer Center, Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, 1011 NW 15th Street, Room 417, Miami, Florida 33136, USA.
Xi ChenSylvester Comprehensive Cancer Center, Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, 1011 NW 15th Street, Room 417, Miami, Florida 33136, USA.
Qun-Tian WangDepartment of Biological Sciences, University of Illinois at Chicago, Chicago, Illinois 60607, USA.
Stephen D NimerSylvester Comprehensive Cancer Center, Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, 1011 NW 15th Street, Room 417, Miami, Florida 33136, USA.
Peng YuDepartment of Electrical and Computer Engineering, and TEES-AgriLife Center for Bioinformatics and Genomic Systems Engineering, Texas A&M University, College Station, Texas 77843, USA.
Qian-Fei WangKey Laboratory of Genomic and Precision Medicine, Collaborative Innovation Center of Genetics and Development, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China.
Mingjiang XuSylvester Comprehensive Cancer Center, Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, 1011 NW 15th Street, Room 417, Miami, Florida 33136, USA.
Feng-Chun YangSylvester Comprehensive Cancer Center, Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, 1011 NW 15th Street, Room 417, Miami, Florida 33136, USA.
University of Miami · USChinese Academy of Sciences · CNTexas A&M University System · USChinese Academy of Medical Sciences & Peking Union Medical College · CN
Funding
Targeting p300 and lysine acetylation in AMLR01CA166835 · NCI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI Stephen D. Nimer · 2012 to 2026
$4.6MRole of Asxl1 in normal hematopoiesis and pathogenesis of myeloid malignanciesR01CA172408 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI XU, MINGJIANG, YANG, FENG-CHUN · 2014 to 2024
$3.4MRole of TET2 in normal hematopoiesis and pathogenesis of myeloid malignanciesR01HL112294 · NHLBI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI XU, MINGJIANG · 2012 to 2016
$1.9MNo-nonsense approach to treat myeloid malignancies with ASXL1 nonsense mutationsR21CA185751 · NCI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI XU, MINGJIANG, YANG, FENG-CHUN · 2014 to 2015
$370kNCI NIH HHS R01 CA166835NCI NIH HHS R01 CA172408NCI NIH HHS R21 CA185751NHLBI NIH HHS R01 HL112294
Abstract
ASXL2 is frequently mutated in acute myeloid leukaemia patients with t(8;21). However, the roles of ASXL2 in normal haematopoiesis and the pathogenesis of myeloid malignancies remain unknown. Here we show that deletion of Asxl2 in mice leads to the development of myelodysplastic syndrome (MDS)-like disease. Asxl2
Indexed as
AnimalsCell LineageCell Self RenewalDisease ProgressionGene DeletionGene Expression Regulation, LeukemicHematopoiesisHematopoietic Stem CellsHistonesLeukemia, Myeloid, AcuteLysineMiceMyelodysplastic SyndromesMyeloid CellsProtein Processing, Post-TranslationalRepressor ProteinsASXL2 protein, mouseHistonesLysineRepressor Proteins
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.