Evidence map›Paper›PMID 28593987›Full record

ArticleNature communications2017

Spaser as a biological probe.

Ekaterina I Galanzha, Robert Weingold, Dmitry A Nedosekin, Mustafa Sarimollaoglu, Jacqueline Nolan, Walter Harrington, Alexander S Kuchyanov, Roman G Parkhomenko, Fumiya Watanabe, Zeid Nima and 4 more

Abstract read
In one paragraph

Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed.

  1. Article
  2. TowardsFundamental research · 2024
    Review
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Review
  10. Article
  11. Review
  12. Article
  13. Article
  14. Biophotonic probes for bio-detection and imaging.Light, science & applications · 2021
    Review
  15. Topological Encoded Vector Beams for Monitoring Amyloid-Lipid Interactions in Microcavity.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Ekaterina I GalanzhaArkansas Nanomedicine Center, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA.
Robert WeingoldArkansas Nanomedicine Center, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA.
Dmitry A NedosekinArkansas Nanomedicine Center, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA.
Mustafa SarimollaogluArkansas Nanomedicine Center, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA.ORCID 0000-0003-0246-9702
Jacqueline NolanArkansas Nanomedicine Center, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA.
Walter HarringtonArkansas Nanomedicine Center, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA.
Alexander S KuchyanovInstitute of Automation and Electrometry of the Siberian Branch of the Russian Academy of Science, Koptyug Avenue 1, Novosibirsk 630090, Russia.
Roman G ParkhomenkoNikolaev Institute of Inorganic Chemistry of the Siberian Branch of the Russian Academy of Science, Lavrentiev Avenue 3, Novosibirsk 630090, Russia.
Fumiya WatanabeCenter for Integrative Nanotechnology Sciences, University of Arkansas at Little Rock, Little Rock, Arkansas 72204, USA.
Zeid NimaCenter for Integrative Nanotechnology Sciences, University of Arkansas at Little Rock, Little Rock, Arkansas 72204, USA.
Alexandru S BirisCenter for Integrative Nanotechnology Sciences, University of Arkansas at Little Rock, Little Rock, Arkansas 72204, USA.
Alexander I PlekhanovInstitute of Automation and Electrometry of the Siberian Branch of the Russian Academy of Science, Koptyug Avenue 1, Novosibirsk 630090, Russia.
Mark I StockmanCenter for Nano-Optics and Department of Physics and Astronomy, Georgia State University, 29 Peachtree Center Avenue, Atlanta, Georgia 30302, USA.ORCID 0000-0002-6996-0806
Vladimir P ZharovArkansas Nanomedicine Center, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA.

Funding

In vivo real-time detection of circulating melanoma cellsR01CA131164 · NCI · UNIV OF ARKANSAS FOR MED SCIS · PI SUEN, JAMES · 2009 to 2019
$3.1M
Photoswitchable nanoprobes for in vivo flow cytometryR01EB017217 · NIBIB · UNIV OF ARKANSAS FOR MED SCIS · PI ZHAROV, VLADIMIR P · 2014 to 2017
$1.3M
NCI NIH HHS R01 CA131164NIBIB NIH HHS R01 EB017217
6 · The paper itself

Abstract

Understanding cell biology greatly benefits from the development of advanced diagnostic probes. Here we introduce a 22-nm spaser (plasmonic nanolaser) with the ability to serve as a super-bright, water-soluble, biocompatible probe capable of generating stimulated emission directly inside living cells and animal tissues. We have demonstrated a lasing regime associated with the formation of a dynamic vapour nanobubble around the spaser that leads to giant spasing with emission intensity and spectral width >100 times brighter and 30-fold narrower, respectively, than for quantum dots. The absorption losses in the spaser enhance its multifunctionality, allowing for nanobubble-amplified photothermal and photoacoustic imaging and therapy. Furthermore, the silica spaser surface has been covalently functionalized with folic acid for molecular targeting of cancer cells. All these properties make a nanobubble spaser a promising multimodal, super-contrast, ultrafast cellular probe with a single-pulse nanosecond excitation for a variety of in vitro and in vivo biomedical applications.

Indexed as

Quantum DotsAnimalsBiocompatible MaterialsCell SurvivalContrast MediaDrug Delivery SystemsFemaleFolic AcidGoldHumansLasersLightMaterials TestingMetal NanoparticlesMiceMice, NudeBiocompatible MaterialsContrast MediaFolic AcidGoldSilicon Dioxide

Identifiers

PMID28593987
PMCPMC5472166

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.