Evidence map›Paper›PMID 28593939›Full record

ArticleNature communications2017

Magnetic forces enable controlled drug delivery by disrupting endothelial cell-cell junctions.

Yongzhi Qiu, Sheng Tong, Linlin Zhang, Yumiko Sakurai, David R Myers, Lin Hong, Wilbur A Lam, Gang Bao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers.

0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

67 citing papers in PubMed.

  1. Review
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  3. Article
  4. Article
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  9. Magnetic FeAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  10. Review
  11. Review
  12. Article
  13. Article
  14. Article
  15. Review
  16. Review
  17. Article
  18. Review
  19. Magneto-Mechanical Actuation Induces Endothelial Permeability.ACS biomaterials science & engineering · 2023
    Article
  20. Review

7 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yongzhi QiuWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, Georgia 30332, USA.
Sheng TongDepartment of Bioengineering, Rice University, Houston, Texas 77005, USA.
Linlin ZhangDepartment of Bioengineering, Rice University, Houston, Texas 77005, USA.
Yumiko SakuraiWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, Georgia 30332, USA.
David R MyersWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, Georgia 30332, USA.
Lin HongDepartment of Bioengineering, Rice University, Houston, Texas 77005, USA.
Wilbur A LamWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, Georgia 30332, USA.
Gang BaoDepartment of Bioengineering, Rice University, Houston, Texas 77005, USA.

Funding

Translational Research SkillsU54HL112309 · NHLBI · EMORY UNIVERSITY · PI LOLLAR, JOHN S. · 2012 to 2016
$12.1M
Endothelialized microfluidics for sickle cell disease research & drug discoveryR01HL121264 · NHLBI · EMORY UNIVERSITY · PI LAM, WILBUR A · 2014 to 2018
$2.0M
NHLBI NIH HHS HHSN268201000043CNHLBI NIH HHS R01 HL121264NHLBI NIH HHS U54 HL112309
6 · The paper itself

Abstract

The vascular endothelium presents a major transport barrier to drug delivery by only allowing selective extravasation of solutes and small molecules. Therefore, enhancing drug transport across the endothelial barrier has to rely on leaky vessels arising from disease states such as pathological angiogenesis and inflammatory response. Here we show that the permeability of vascular endothelium can be increased using an external magnetic field to temporarily disrupt endothelial adherens junctions through internalized iron oxide nanoparticles, activating the paracellular transport pathway and facilitating the local extravasation of circulating substances. This approach provides a physically controlled drug delivery method harnessing the biology of endothelial adherens junction and opens a new avenue for drug delivery in a broad range of biomedical research and therapeutic applications.

Indexed as

Magnetic FieldsAdherens JunctionsAnimalsCapillary PermeabilityCell LineDrug Delivery SystemsEndothelial CellsEndothelium, VascularHumansHuman Umbilical Vein Endothelial CellsMiceMice, Nude

Identifiers

PMID28593939
PMCPMC5472756

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.