ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2017
FRAX for fracture prediction shorter and longer than 10 years: the Manitoba BMD registry.
Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Article
- An enhanced Fracture Risk Evaluation Model (FREM) using national health data on morbidity and medications.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2025Article
- Assessment of the risk of osteoporotic bone fracture in postmenopausal women using machine learning methods.Scientific reports · 2025Article
- External validation of FRISBEE 2-year and 5-year fracture prediction models in a fracture liaison service cohort.Archives of osteoporosis · 2025Article
- Biases in the performance of FRAX without BMD in predicting fracture risk in a multiethnic population with diabetes: the Diabetes and Aging Study.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2025Article
- An electronic health record (EHR)-based risk calculator can predict fractures comparably to FRAX: a proof-of-concept study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2024Article
- Hip fracture rate and osteoporosis treatment in Ontario: A population-based retrospective cohort study.Archives of osteoporosis · 2024Article
- Hip Fracture Risk Assessment Tools for Adults Aged 80 Years and Older.JAMA network open · 2024Article
- Electronic Health Records (EHRs) Can Identify Patients at High Risk of Fracture but Require Substantial Race Adjustments to Currently Available Fracture Risk Calculators.Journal of general internal medicine · 2023Article
- Adjusting FRAX Estimates of Fracture Probability Based on a Positive Vertebral Fracture Assessment.JAMA network open · 2023Article
- The effect of fracture recency on observed 5-year fracture probability: A study based on the FRISBEE cohort.Bone reports · 2023Article
- Establishment of a preliminary FRAX®-based intervention threshold for rheumatoid arthritis-associated fragility fracture: a 3-year longitudinal, observational, cohort study.Therapeutic advances in chronic disease · 2022Article
- Independent External Validation of FRAX and Garvan Fracture Risk Calculators: A Sub-Study of the FRISBEE Cohort.JBMR plus · 2021Article
- Preventing hip fractures with multidisciplinary teams: a Canadian perspective.Canadian journal of surgery. Journal canadien de chirurgie · 2021Review
- The use of 2-, 5-, and 10-year probabilities to characterize fracture risk after a recent sentinel fracture.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2021Article
- Testing a theoretical model of imminent fracture risk in elderly women: an observational cohort analysis of the Canadian Multicentre Osteoporosis Study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2020Article
- New Developments in Fracture Risk Assessment for Current Osteoporosis Reports.Current osteoporosis reports · 2020Review
- Deterioration of Cortical and Trabecular Microstructure Identifies Women With Osteopenia or Normal Bone Mineral Density at Imminent and Long-Term Risk for Fragility Fracture: A Prospective Study.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2020Article
- Healthcare Policy Changes in Osteoporosis Can Improve Outcomes and Reduce Costs in the United States.JBMR plus · 2019Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In a large clinical registry for the province of Manitoba, Canada, FRAX predicted incident MOF and hip fracture from 1 to 15 years following baseline assessment. A simple linear rescaling of FRAX outputs seems useful for predicting both short- and long-term fracture risk in this population.
introductionFRAX® estimates 10-year probability of major osteoporotic fracture (MOF) and hip fracture. We examined FRAX predictions over intervals shorter and longer than 10 years.
methodsUsing a population-based clinical registry for Manitoba, Canada, we identified 62,275 women and 6455 men 40 years and older with baseline dual-energy X-ray absorptiometry scans and FRAX scores. Incident MOF and hip fracture were assessed up to 15 years from population-based data. We assessed agreement between estimated fracture probability from 1 to 15 years using linearly rescaled FRAX scores and observed cumulative fracture probability. The gradient of risk for FRAX probability and incident fracture was examined overall and for 5-year intervals.
resultsFRAX predicted incident MOF and hip fracture for all time intervals. There was no attenuation in the gradient of risk for MOF even for years >10. Gradient of risk was slightly lower for hip fracture prediction in years >10 vs years <5, though HRs remained high. Linear agreement was seen in the relationships between observed vs predicted (rescaled) FRAX probabilities (R
conclusionsFRAX predicts incident MOF and hip fracture up to 15 years and could be adapted to predict fracture over time periods shorter and longer term than 10 years in populations with fracture and mortality epidemiology similar to Canada.
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