ArticleeNeuro
Intravenous Heroin Induces Rapid Brain Hypoxia and Hyperglycemia that Precede Brain Metabolic Response.
Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 47 citations in OpenAlex.
- Bilateral Ulnar Neuropathy Secondary to Chronic Pentazocine Injections: A Rare Neurological Sequela of Substance Abuse.Clinical case reports · 2026Article
- Brain oxygen responses induced by arousing stimuli and fentanyl: generalized or structure-specific?American journal of physiology. Regulatory, integrative and comparative physiology · 2026Article
- Article
- Using miniscopes and deep learning to compare neurobehavioral representations of psychostimulant and opioid self-administration.Addiction neuroscience · 2025Article
- Neurotoxicity mechanisms and clinical implications of six common recreational drugs.Frontiers in pharmacology · 2025Review
- Hypoxic effects of heroin and fentanyl and their basic physiological mechanisms.American journal of physiology. Lung cellular and molecular physiology · 2024Review
- Article
- Oxygen fluctuations in the brain and periphery induced by intravenous fentanyl: effects of dose and drug experience.Journal of neurophysiology · 2024Article
- Ventilatory Effects of Fentanyl, Heroin, andThe Journal of pharmacology and experimental therapeutics · 2024Article
- Brain oxygen responses induced by opioids: focus on heroin, fentanyl, and their adulterants.Frontiers in psychiatry · 2024Review
- Hippocampal volume loss in individuals with a history of non-fatal opioid overdose.Addiction biology · 2023Article
- Xylazine effects on opioid-induced brain hypoxia.Psychopharmacology · 2023Article
- The pattern of brain oxygen response induced by intravenous fentanyl limits the time window of therapeutic efficacy of naloxone.Neuropharmacology · 2023Article
- Basic metabolic and vascular effects of ketamine and its interaction with fentanyl.Neuropharmacology · 2023Article
- Effects of current smoking severity on brain gray matter volume in opioid use disorder - a voxel-based morphometry study.The American journal of drug and alcohol abuse · 2023Article
- Methadone maintenance treatment is more effective than compulsory detoxification in addressing gut microbiota dysbiosis caused by heroin abuse.Frontiers in microbiology · 2023Article
- Comparison of the effects of fentanyls and otherFrontiers in pharmacology · 2023Article
- Analysis of heroin effects on calcium channels in rat cardiomyocytes based on transcriptomics and metabolomics.Open medicine (Warsaw, Poland) · 2023Article
- Article
- Rapid fluctuations in brain oxygenation during glucose-drinking behavior in trained rats.Journal of neurophysiology · 2022Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Heroin use and overdose have increased in recent years as people transition from abusing prescription opiates to using the cheaper street drug. Despite a long history of research, many physiological effects of heroin and their underlying mechanisms remain unknown. Here, we used high-speed amperometry to examine the effects of intravenous heroin on oxygen and glucose levels in the nucleus accumbens (NAc) in freely-moving rats. Heroin within the dose range of human drug use and rat self-administration (100-200 μg/kg) induced a rapid, strong, but transient drop in NAc oxygen that was followed by a slower and more prolonged rise in glucose. Using oxygen recordings in the subcutaneous space, a densely-vascularized site with no metabolic activity, we confirmed that heroin-induced brain hypoxia results from decreased blood oxygen, presumably due to drug-induced respiratory depression. Respiratory depression and the associated rise in CO
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.