ArticleCellular and molecular gastroenterology and hepatology2017
Columnar Metaplasia in Three Types of Surgical Mouse Models of Esophageal Reflux.
Article in Cellular and molecular gastroenterology and hepatology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 14 citations in OpenAlex.
- Advancing Esophageal Disease Modeling: Microfluidic Platforms for Adult Tissue-Resident Stem Cell Culture and Differentiation.Gastro hep advances · 2026Article
- Signaling Pathways in the Pathogenesis of Barrett's Esophagus and Esophageal Adenocarcinoma.International journal of molecular sciences · 2023Review
- P63 Deficiency and CDX2 Overexpression Lead to Barrett's-Like Metaplasia in Mouse Esophageal Epithelium.Digestive diseases and sciences · 2021Article
- Dedifferentiation of esophageal progenitors in metaplasia and cancer.Molecular & cellular oncology · 2021Article
- Pathogenesis and Cells of Origin of Barrett's Esophagus.Gastroenterology · 2019Review
- Host factors influence Barrett's carcinogenesis: findings from a mouse gastroduodenal reflux model.Esophagus : official journal of the Japan Esophageal Society · 2019Article
- Mind the Gap: Crossing Boundaries to Establish Reparative Metaplasia.Cellular and molecular gastroenterology and hepatology · 2018Article
- Columnar-Lined Esophagus Develops via Wound Repair in a Surgical Model of Reflux Esophagitis.Cellular and molecular gastroenterology and hepatology · 2018Article
- Of Mice and Men and Metaplasia.Cellular and molecular gastroenterology and hepatology · 2017Article
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimsEsophageal adenocarcinoma develops in the setting of gastroesophageal reflux and columnar metaplasia in distal esophagus. Columnar metaplasia arising in gastroesophageal reflux models has developed in rat; however, gastroesophageal reflux models in mice have not been well-characterized.
methodsOne hundred thirty-five C57Bl/6J mice aged 8 weeks old were divided into the following operations: esophagogastrojejunostomy (side-to-side) (EGJ), esophageal separation and esophagojejunostomy (end-to-side) (EJ), and EJ and gastrectomy (end-to-side) (EJ/TG). The animals were euthanized after 40 weeks and the histology of the junction was examined. Immunohistochemistry for p53, PDX-1, and CDX-2 was performed.
resultsMetaplasia developed in 15/33 (45.5%) of EGJ, 0/38 (0%) of EJ, and 6/39 (15.4%) of EJ/TG (
conclusionsThe EGJ model, which causes reflux of gastric acid and duodenal content, developed metaplasia and dysplasia most frequently. No metaplasia developed in the EJ model in which gastric juice and duodenal content mixed before reflux. Thus, duodenal contents alone can induce columnar metaplasia and dysplasia; however, the combination of gastric acid with duodenal content reflux can cause metaplasia and dysplasia more efficiently.
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