Evidence map›Paper›PMID 28593178›Full record

ArticleJournal of immunology research2017

Association of Toll-Like Cell Receptors TLR2 (p.Arg753GLN) and TLR4 (p.Asp299GLY) Polymorphisms with Indicators of General and Local Immunity in Patients with Atopic Dermatitis.

Yury A Tyurin, Anton F Shamsutdinov, Nikolay N Kalinin, Alsou A Sharifullina, Irina D Reshetnikova

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of immunology research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Review
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  6. Article
  7. Article
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  11. Cytokines and apoptosis in atopic dermatitis.Postepy dermatologii i alergologii · 2021
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Yury A TyurinDepartment of Biochemistry and Clinical Laboratory Diagnostics, Kazan State Medical University, 49 Butlerov Street, Kazan 420012, Russia.ORCID 0000-0002-2536-3604
Anton F ShamsutdinovInstitute of Fundamental Medicine and Biology, Kazan Federal University, 18 Kremlevskaya Street, Kazan 420008, Russia.
Nikolay N KalininThe I.M. Sechenov First Moscow State Medical University, 8-2 Trubetskaya Street, Moscow 119991, Russia.
Alsou A SharifullinaLaboratory of Immunology and the Development of Allergens, Kazan Research Institute of Epidemiology and Microbiology, 67 Big Red Street, Kazan 420015, Russia.
Irina D ReshetnikovaLaboratory of Immunology and the Development of Allergens, Kazan Research Institute of Epidemiology and Microbiology, 67 Big Red Street, Kazan 420015, Russia.
Kazan Research Institute of Epidemiology and Microbiology · RUKazan Federal University · RUKazan State Medical University · RUSechenov University · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A whole group of polymorphisms of genes involved in the formation of the epidermal barrier, immune responses, and their regulation is important in the formation of atopic phenotype. The purpose of the study is to determine the relationship of polymorphisms of genes of Toll-like receptors TLR2 and TLR4 with clinical and immunological parameters in atopic dermatitis patients in a "case-control" study. Polymorphisms of genes TLR2 (p.Arg753Gln) and TLR4 (Asp299Gly) were detected by PCR. Parameters of the state of innate and adaptive immunity were assessed by the level of local production of sIgA, cytokine profile of blood serum for IL-4, IL-10, and IFN-

Indexed as

Adaptive ImmunityAdolescentAdultCase-Control StudiesChildChild, PreschoolDermatitis, AtopicFemaleGenetic Predisposition to DiseaseGenotypeHumansImmunity, InnateImmunoglobulin A, SecretoryInterferon-gammaInterleukin-10Interleukin-4Immunoglobulin A, SecretoryInterferon-gammaInterleukin-10Interleukin-4TLR2 protein, humanTLR4 protein, humanToll-Like Receptor 2Toll-Like Receptor 4

Identifiers

PMID28593178
PMCPMC5448057
OpenAlexW2615234940

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.