Evidence map›Paper›PMID 28593171›Full record

ArticleProstate international2017

Anand Setty Balakrishnan, Abel Arul Nathan, Mukesh Kumar, Sudhakar Ramamoorthy, Sathish Kumar Ramia Mothilal

Open access · goldAbstract read
In one paragraph

Article in Prostate international, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 21 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Pharmaceutics · 2022
    Review
  6. Critical review of theBulletin of the National Research Centre · 2021
    Review
  7. A Perspective onJournal of immunology research · 2021
    Review
  8. Journal of traditional and complementary medicine · 2020
    Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Anand Setty BalakrishnanDepartment of Genetic Engineering, School of Biotechnology, Madurai Kamaraj University, Madurai, India.
Abel Arul NathanDepartment of Genetic Engineering, School of Biotechnology, Madurai Kamaraj University, Madurai, India.
Mukesh KumarDepartment of Genetic Engineering, School of Biotechnology, Madurai Kamaraj University, Madurai, India.
Sudhakar RamamoorthyDepartment of Pathology, Velammal Medical College Hospital & Research Institute, Madurai, India.
Sathish Kumar Ramia MothilalDepartment of Urology, Velammal Medical College Hospital & Research Institute, Madurai, India.
Madurai Kamaraj University · INVelammal Medical College Hospital and Research Institute · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundProstate cancer (PC) is a common noncutaneous malignancy in men. The incidence of PC is increasing at an alarming rate across the globe. Progression of PC is associated with elevated levels of interleukin-8 (IL-8) and cyclooxygenase-2 (COX-2) in malignant cells. Overexpression of these players is accompanied by chronic inflammation, increased angiogenesis, proliferation, migration, and inhibition of apoptosis. Moreover, their elevated circulating levels promote the disease progression from androgen-dependent to androgen-independent state. Thus, inhibiting the expression of IL-8 and COX-2 would be a promising target in the development of PC therapeutics. In this study, we investigated the inhibitory effects of MATERIALS AND

methodsThe cell viability and cytotoxicity of

resultsWe observed a significant decrease in the cell viability with a half-maximal inhibitory concentration (IC

conclusionOur results indicate that inherent metastatic and selective inhibitory potential of

Indexed as

Androgen-independent cellsCyclooxygenase-2Interleukin-8Prostatic adenocarcinomaWithania somnifera

Identifiers

PMID28593171
PMCPMC5448731
OpenAlexW2595224193

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.