ReviewSafety and health at work2017
Occupational Exposure to Knee Loading and the Risk of Osteoarthritis of the Knee: A Systematic Review and a Dose-Response Meta-Analysis.
Review in Safety and health at work, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
48 citing papers in PubMed, 6 syntheses or guidelines pooled it, 109 citations in OpenAlex.
- Systematic Review of Workplace Interventions to Support Young Workers' Safety, Work Environment and Health.Journal of occupational rehabilitation · 2025Pooled it
- Work-relatedness of inguinal hernia: a systematic review including meta-analysis and GRADE.Hernia : the journal of hernias and abdominal wall surgery · 2020Pooled it
- Occupational Risk in Knee Osteoarthritis: A Systematic Review and Meta-Analysis of Observational Studies.Arthritis care & research · 2020Pooled it
- Men and Women's Occupational Activities and the Risk of Developing Osteoarthritis of the Knee, Hip, or Hands: A Systematic Review and Recommendations for Future Research.Arthritis care & research · 2020Pooled it
- How to improve the assessment of the impact of occupational diseases at a national level? The Netherlands as an example.Occupational and environmental medicine · 2019Pooled it
- Work-relatedness of lumbosacral radiculopathy syndrome: Review and dose-response meta-analysis.Neurology · 2018Pooled it
- Integrating participatory ergonomic management in non-weight-bearing exercise and progressive resistance exercise on self-care and functional ability in aged farmers with knee osteoarthritis: a clustered randomized controlled trial.Clinical interventions in aging · 2018Trial
- Occupational physical behaviors and knee pain among eldercare workers: A prospective accelerometer study.Scandinavian journal of work, environment & health · 2026Article
- Relationship Between Magnetic Resonance Imaging-based Knee Cartilage Loss and Work-related Physical Workload in Farmers and Fishers.Safety and health at work · 2026Article
- Diagnosing and Reporting of Occupational Diseases: An Assessment Study of Reports from an Italian Workplace Safety Prevention Program Service.La Medicina del lavoro · 2025Article
- List of occupational diseases among farmers in Korea: a literature review.Annals of occupational and environmental medicine · 2025Review
- Osteoarthritis, osteoarthritis treatment and risk of incident dementia: a prospective cohort study based on UK Biobank.Age and ageing · 2024Article
- Physical Work Demands of Maintenance Workers on Onshore Petroleum Facilities in Norway: An Observational Study Utilizing Wearable Sensor Technology.Annals of work exposures and health · 2023Observational
- Does Consulting an Occupational Medicine Specialist Decrease Time to Return to Work Among Total Knee Arthroplasty Patients? A 12-Month Prospective Multicenter Cohort Study.Journal of occupational rehabilitation · 2023Article
- Finite element analysis of a healthy knee joint at deep squatting for the study of tibiofemoral and patellofemoral contact.Journal of orthopaedics · 2023Article
- A Health-Impact Assessment of an Ergonomic Measure to Reduce the Risk of Work-Related Lower Back Pain, Lumbosacral Radicular Syndrome and Knee Osteoarthritis among Floor Layers in The Netherlands.International journal of environmental research and public health · 2023Article
- Impact of Occupation on 12-Month Outcomes After Anterior Cruciate Ligament Reconstruction in Male Patients.Orthopaedic journal of sports medicine · 2023Article
- Estimation and Comparison of Knee Joint Contact Forces During Heel Contact and Heel Rise Deep Squatting.Indian journal of orthopaedics · 2023Article
- A first step towards a framework for interventions for individual working practice to prevent work-related musculoskeletal disorders: a scoping review.BMC musculoskeletal disorders · 2023Article
- Risk of symptomatic osteoarthritis associated with exposure to ergonomic factors at work in a nationwide Italian survey.International archives of occupational and environmental health · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOsteoarthritis of the knee is considered to be related to knee straining activities at work. The objective of this review is to assess the exposure dose-response relation between kneeling or squatting, lifting, and climbing stairs at work, and knee osteoarthritis.
methodsWe included cohort and case-control studies. For each study that reported enough data, we calculated the odds ratio (OR) per 5,000 hours of cumulative kneeling and per 100,000 kg of cumulative lifting. We pooled these incremental ORs in a random effects meta-analysis.
resultsWe included 15 studies (2 cohort and 13 case-control studies) of which nine assessed risks in more than two exposure categories. We considered all but one study at high risk of bias. The incremental OR per 5,000 hours of kneeling was 1.26 (95% confidence interval 1.17-1.35, 5 studies, moderate quality evidence) for a log-linear exposure dose-response model. For lifting, there was no exposure dose-response per 100,000 kg of lifetime lifting (OR 1.00, 95% confidence interval 1.00-1.01). For climbing, an exposure dose-response could not be calculated.
conclusionThere is moderate quality evidence that longer cumulative exposure to kneeling or squatting at work leads to a higher risk of osteoarthritis of the knee. For other exposure, there was no exposure dose-response or there were insufficient data to establish this. More reliable exposure measurements would increase the quality of the evidence.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.