Evidence map›Paper›PMID 28593043›Full record

ArticleAntimicrobial resistance and infection control2017

Diffusion of clindamycin-resistant and erythromycin-resistant methicillin-susceptible

Margaret Carrel, Michihiko Goto, Marin L Schweizer, Michael Z David, Daniel Livorsi, Eli N Perencevich

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Antimicrobial resistance and infection control, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02216227 (Checklist to Prevent MRSA Surgical Site Infections), which is not on this map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02216227 nacompletednot on this map

Checklist to Prevent MRSA Surgical Site Infections

TypeinterventionalSponsorVA Office of Research and DevelopmentRan2014 to 2021Enrolled23,005ConditionsSurgical Site InfectionArmsMupirocin, Chlorhexidine gluconate, Cefazolin, Vancomycin, Nasal Povidone Iodine
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 13 citations in OpenAlex.

  1. Persistence of potential ST398 MSSA in outpatient settings among US veterans, 2010-2019.Antimicrobial stewardship & healthcare epidemiology : ASHE · 2023
    Article
  2. Article
  3. TheGenes · 2021
    Review
  4. Article
  5. Increasing incidence of bloodstream infections due to Staphylococcus aureus clonal complex 398 in a French hospital between 2010 and 2017.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2019
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Margaret CarrelDepartment of Geographical & Sustainability Sciences, University of Iowa, 305 Jessup Hall, Iowa City, IA 52242 USA.ORCID 0000-0003-0430-9235
Michihiko GotoIowa City VA Health Care System, Iowa City, IA USA.
Marin L SchweizerIowa City VA Health Care System, Iowa City, IA USA.
Michael Z DavidDepartment of Medicine, The University of Chicago Biological Sciences, Chicago, IL USA.
Daniel LivorsiIowa City VA Health Care System, Iowa City, IA USA.
Eli N PerencevichIowa City VA Health Care System, Iowa City, IA USA.
University of Iowa · USUniversity of Chicago · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundChanging phenotypic profiles of methicillin-susceptible

methodsA retrospective cohort of all patients with MSSA invasive infections, defined as a positive clinical culture from a sterile site, during 2003-2014 was created. Only isolates tested against clindamycin, erythromycin and tetracycline were included. Annual hospital-level proportions of potential ST398 were compared according to facility distance from NYC and region.

resultsA total of 34,025 patient isolates from 136 VA medical centers met the inclusion criteria. Of those, 4582 (13.5%) met the definition of potential ST398. Potential ST398 increased over the 12-year cohort and diffused outwards from NYC. Incidence Rate Ratios of >1.0 (

conclusionsWe observe an increase in the phenotypic profile of potential ST398 MSSA isolates in invasive infections in a national cohort of patients in the US. The increase is not evenly distributed across the US but appears to diffuse outwards from NYC. Novel MSSA strain emergence may have important clinical implications, particularly for the use of clindamycin for suspected

Indexed as

DiffusionEmergenceMSSASpatiotemporal analysisST398

Identifiers

PMID28593043
PMCPMC5460425
OpenAlexW2624516015

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.