Evidence map›Paper›PMID 28592954›Full record

ArticleEnvironmental chemistry letters2015

Pharmaceuticals and personal care products in waters: occurrence, toxicity, and risk.

Leslie Cizmas, Virender K Sharma, Cole M Gray, Thomas J McDonald

Abstract read
In one paragraph

Article in Environmental chemistry letters, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Photochemical reactivity and fate of the toxic transformation product of naproxen in water.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2026
    Article
  4. Article
  5. Impact of therapeutic pharmaceuticals on water bodies: diagnosis, ecological threat, and removal strategies.Water science and technology : a journal of the International Association on Water Pollution Research · 2025
    Article
  6. Review
  7. Review
  8. Article
  9. Review
  10. Greywater Reuse: Contaminant Profile, Health Implications, and Sustainable Solutions.International journal of environmental research and public health · 2025
    Review
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Leslie CizmasDepartment of Environmental and Occupational Health, School of Public Health, Texas A&M University, College Station, TX 77843, USA.
Virender K SharmaDepartment of Environmental and Occupational Health, School of Public Health, Texas A&M University, College Station, TX 77843, USA.
Cole M GrayDepartment of Environmental and Occupational Health, School of Public Health, Texas A&M University, College Station, TX 77843, USA.
Thomas J McDonaldDepartment of Environmental and Occupational Health, School of Public Health, Texas A&M University, College Station, TX 77843, USA.

Funding

TARGETED GENOMICS FACILITY COREP30ES023512 · NIEHS · TEXAS A&M AGRILIFE RESEARCH · PI DEUTZ, NICOLAAS E · 2014 to 2017
$3.3M
NIEHS NIH HHS P30 ES023512
6 · The paper itself

Abstract

Pharmaceuticals and personal care products (PPCP) are compounds with special physical and chemical properties that address the care of animal and human health. PPCP have been detected in surface water and wastewater in the ng/L to µg/L concentration range worldwide. PPCP ecotoxicity has been studied in a variety of organisms, and multiple methods have been used to assess the risk of PPCP in the environment to ecological health. Here we review the occurrence, effects, and risk assessment of PPCP in aquatic systems, as well as the sustainability of current methods for managing PPCP contamination in aquatic systems. The major points are the following: (1) a number of PPCP present potential concerns at environmentally relevant concentrations. PPCP mixtures may produce synergistic toxicity. (2) Various methods have been used for the ecological risk assessment of PPCP in aquatic systems. There are similarities in these methods, but no consensus has emerged regarding best practices for the ecological risk assessment of these compounds. (3) Human health risk assessments of PPCP contamination in aquatic systems have generally indicated little cause for concern. However, there is a lack of information regarding whether antibiotic contamination in wastewater and aquatic systems could lead to an increase in clinically relevant antibiotic-resistant bacteria and antibiotic-resistant genes. (4) Over the next century, the combination of increasing global population size and potential droughts may result in reduced water availability, increased need for water reuse, and increasing concentrations of PPCP in wastewaters. The current wastewater treatment methods do not remove all PPCP effectively. This, coupled with the possibility that antibiotics may promote the development of antibiotic-resistant bacteria and antibiotic-resistant genes, leads to concerns about the sustainability of global water supplies.

Indexed as

Antibiotic resistanceAntibiotic-resistant bacteriaAntibiotic-resistant genesAquatic systemsEnvironmentPersonal care productsPharmaceuticalsReviewRiskSustainability

Identifiers

PMID28592954
PMCPMC5459316

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.