ArticleScientific reports2017
The shape and size of hydroxyapatite particles dictate inflammatory responses following implantation.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 87 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
87 citing papers in PubMed, 217 citations in OpenAlex.
- NLRP3 inflammasome activation by particles and fibers: implications for human hazard assessment.Archives of toxicology · 2026Review
- Enhancing Regenerative Outcomes: Histopathological Comparison of Calcium Hydroxylapatite Alone and Combined With Platelet-rich Fibrin: A 6-week Study.Plastic and reconstructive surgery. Global open · 2026Article
- Differential Modulation of Extracellular Matrix- and Longevity-Related Gene Expression by Calcium Hydroxylapatite Formulations.Life (Basel, Switzerland) · 2026Article
- Progress in Hydroxyapatite Nanocarriers for Targeted and Enhanced Osteoporosis Treatment: A Comprehensive Review.Molecular biotechnology · 2026Review
- Shape-defined poly(lactic acid)-nanohydroxyapatite composite microparticles modulate osteogenic differentiation in 3D microtissues of human mesenchymal stromal cells.Materials today. Bio · 2026Article
- Applicability of Whole Blood Monocyte Activation Test for Endotoxin Activity Assessment in Hydroxyapatite-Based Ceramics.Bioengineering (Basel, Switzerland) · 2026Article
- Engineered bone matrix models for understanding breast cancer skeletal metastasis.Cancer metastasis reviews · 2026Review
- Bone matrix-mimetic multi-ion doped hydroxyapatite nanorod arrays for enhanced immuno-osteogenesis and prevention of aseptic loosening.Bioactive materials · 2026Article
- Nasal immunization with Streptococcus mutans membrane vesicles and eggshell-derived hydroxyapatites elicits enhanced antigen-specific mucosal IgA responses.Scientific reports · 2025Article
- Eco-friendly synthesis of eggshell-derived nano-hydroxyapatite: physicochemical characterization, hemocompatibility, and bone regeneration potential.Scientific reports · 2025Article
- Thermal Treatment and Polymer Matrix Diffusion Effects on Hydroxyapatite Particle Size Evolution.Polymers · 2025Article
- Comparative Analysis of Reconstitution and Solubility of Two Poly-L-Lactic Acid Fillers for Medical Applications.Polymers · 2025Article
- Article
- The Reevaluation of Subgingival Calculus: A Narrative Review.Dentistry journal · 2025Review
- Advances of Hydroxyapatite Nanoparticles in Dental Implant Applications.International dental journal · 2025Review
- Engineering the Immune Response to Biomaterials.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- Bone mineral density affects tumor growth by shaping microenvironmental heterogeneity.Biomaterials · 2025Article
- Pro-Inflammatory Response to Macrotextured Silicone Implant Wear Debris.Tribology letters · 2025Article
- Laser and scanning electron microscopy evaluation of residual microislands of calculus.Journal of periodontology · 2025Article
- Zoledronate and Clodronate affecting bone repair in non-critical defects grafted with carbonated nanostructured hydroxyapatite: anBiomaterial investigations in dentistry · 2025Article
27 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The extent of regeneration following biomaterial implantation is dependent on the microenvironment surrounding the implant. Since implant composition can have a profound effect on inflammation, it is essential to understand this process as a non-resolving inflammatory response can lead to fibrous encapsulation and insufficient integration. Incorporation of particulates into implants confers structural and functional benefits, thus optimizing particulate characteristics to enhance immune mediated efficacy is important. We investigated the relationship between the nature of hydroxyapatite (HA) particles and the innate immune response, focusing on how particle size (0.1 µm, 5 µm, 20 µm, 100 µm) and morphology (needle-shaped/spherical; smooth/rough surface) modulates inflammatory responses. We observed a shape and size-dependent activation of the NLRP3 inflammasome and IL-1β secretion; while needle-shaped and smaller HA particles significantly enhanced cytokine secretion, larger particles did not. Moreover, HA particle characteristics profoundly influenced patterns of innate immune cell recruitment and cytokine production following injection. While small, needle-shaped particles induced a strong inflammatory response, this was not observed with smooth, spherical particles of comparable size or with larger particles. These findings indicate that hydroxyapatite particle characteristics dictate immune cell recruitment and the ensuing inflammatory response, providing an opportunity to tailor HA particle characteristics to regulate immune responses induced after biomaterial implantation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.