ArticleScientific reports2017
Statistical Analysis of Zebrafish Locomotor Behaviour by Generalized Linear Mixed Models.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Refining methodological approaches for analysing higher-throughput locomotor behaviour, using generalized additive mixed models.Frontiers in toxicology · 2026Article
- Tensor analysis of animal behavior by matricization and feature selection.Computers in biology and medicine · 2025Article
- An Analysis of the Movement Trajectories of the EndangeredAnimals : an open access journal from MDPI · 2025Article
- A data analysis approach for locomotor behavioral responses in developmentally exposed zebrafish.NAM journal · 2025Article
- A robust paradigm for studying regeneration after traumatic spinal cord injury in zebrafish.Journal of neuroscience methods · 2024Article
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- An updated review on animal models to study attention-deficit hyperactivity disorder.Translational psychiatry · 2024Review
- Key HPI axis receptors facilitate light adaptive behavior in larval zebrafish.Scientific reports · 2024Article
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- Cannabidiol improves haloperidol-induced motor dysfunction in zebrafish: a comparative study with a dopamine activating drug.Journal of cannabis research · 2023Article
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- Standardized Method for the Assessment of Behavioral Responses of Zebrafish Larvae.Biomedicines · 2021Article
- L-Carnitine ameliorates congenital myopathy in a tropomyosin 3 de novo mutation transgenic zebrafish.Journal of biomedical science · 2021Article
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- Rods Contribute to Visual Behavior in Larval Zebrafish.Investigative ophthalmology & visual science · 2020Article
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- Comparison of Zebrafish Larvae and hiPSC Cardiomyocytes for Predicting Drug-Induced Cardiotoxicity in Humans.Toxicological sciences : an official journal of the Society of Toxicology · 2019Article
- Teratological and Behavioral Screening of the National Toxicology Program 91-Compound Library in Zebrafish (Danio rerio).Toxicological sciences : an official journal of the Society of Toxicology · 2019Article
- Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
Upon a drastic change in environmental illumination, zebrafish larvae display a rapid locomotor response. This response can be simultaneously tracked from larvae arranged in multi-well plates. The resulting data have provided new insights into neuro-behaviour. The features of these data, however, present a challenge to traditional statistical tests. For example, many larvae display little or no movement. Thus, the larval responses have many zero values and are imbalanced. These responses are also measured repeatedly from the same well, which results in correlated observations. These analytical issues were addressed in this study by the generalized linear mixed model (GLMM). This approach deals with binary responses and characterizes the correlation of observations in the same group. It was used to analyze a previously reported dataset. Before applying the GLMM, the activity values were transformed to binary responses (movement vs. no movement) to reduce data imbalance. Moreover, the GLMM estimated the variations among the effects of different well locations, which would eliminate the location effects when two biological groups or conditions were compared. By addressing the data-imbalance and location-correlation issues, the GLMM effectively quantified true biological effects on zebrafish locomotor response.
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Registered trials
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