ArticleJournal of occupational health2017
Possible changes of New-Generation inflammation markers with occupational lead exposure.
Article in Journal of occupational health, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed, 11 citations in OpenAlex.
- A Cross-Sectional Study on Immune-Inflammatory Responses: Exposure to Polycyclic Aromatic Hydrocarbons Alters Pteridine Metabolism and Activates the Kynurenine Pathway.Chemical research in toxicology · 2026Article
- Comparison between plasma neopterin and the urine neopterin:creatinine ratio as inflammatory biomarkers.African health sciences · 2019Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesOccupational lead (Pb) exposure is still an important health problem in the world. Long-term Pb exposure causes several adverse effects. The aim of this study was to investigate the changes of inflammation markers with chronic Pb exposure by analyzing neopterin levels and kynurenine (Kyn) to tryptophan (Trp) ratio that reflects indolamine 2,3-dioxygenase activity and to compare with healthy volunteers' parameters.
methodsBlood lead levels (BLLs) were analyzed by atomic absorption spectrometry. Urinary neopterin and serum Kyn and Trp levels were analyzed by high-performance liquid chromatography.
resultsAccording to our results, mean BLL of the 29 workers was 20.4±9.6 μg/dl. Urinary neopterin levels, serum Kyn levels, and Kyn/Trp of Pb workers (188±52 μmol/mol creatinine, 2.70±0.66 μM, and 43.19±10.38 μmol/mmol, respectively) were significantly higher than controls (144±35 μmol/mol creatinine, 2.08±0.34 μM, and 32.24±7.69 μmol/mmol, respectively). Pb-exposed workers were divided into further three groups according to their BLLs: as 10-19 μg/dl (n=18), 20-29 μg/dl (n=8), and 30-49 μg/dl (n=3). Neopterin levels of the workers with BLL of 30-49 μg/dl were significantly higher than those of BLL with 10-29 μg/dl, while Trp levels decreased. Kyn/Trp of workers with BLL of 30-49 μg/dl were elevated significantly compared with the workers with BLL<30 μg/dl. In addition to neopterin, Kyn and Kyn/Trp levels were positively influenced by Pb exposure.
conclusionsIncreased level of inflammation markers confirms the adverse effects of Pb even low BLLs, and we suggest that monitoring BLLs with inflammation markers could help to prevent serious occupational health problems.
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