Evidence map›Paper›PMID 28592688›Full record

ArticleJournal of neurophysiology2017

Validation of electrical stimulation models: intracellular calcium measurement in three-dimensional scaffolds.

Robert D Adams, Brinda Gupta, Amy B Harkins

Abstract readValidation Study
In one paragraph

Article in Journal of neurophysiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Ratio-based indicators for cytosolic CaProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  4. Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Robert D AdamsDepartment of Pharmacology and Physiology, Saint Louis University School of Medicine, St. Louis, Missouri; and.
Brinda GuptaDepartment of Pharmacology and Physiology, Saint Louis University School of Medicine, St. Louis, Missouri; and.
Amy B HarkinsDepartment of Pharmacology and Physiology, Saint Louis University School of Medicine, St. Louis, Missouri; and harkinsa@slu.edu.

Funding

Pharmacological Sciences Training GrantT32GM008306 · NIGMS · SAINT LOUIS UNIVERSITY · PI EGAN, TERRANCE M, WALKER, JOHN K. · 1990 to 2020
$3.6M
Developing an Electrochemical Assay to Detect Nerve Regeneration in 3D ScaffoldsR03EB015048 · NIBIB · SAINT LOUIS UNIVERSITY · PI HARKINS, AMY B · 2013 to 2014
$148k
NIBIB NIH HHS R03 EB015048NIGMS NIH HHS T32 GM008306
6 · The paper itself

Abstract

Peripheral nerve injury can be disabling. Regeneration is limited by the rate of axonal extension, and proximal injury to peripheral nerves can take over a year to reach target organs. Electrical stimulation (ES) has been shown to increase the rate of neurite growth, though the mechanism is not yet well understood. In our prior manuscript, we developed a computational model that demonstrates how ES can functionally elevate intracellular calcium concentration ([Ca

Indexed as

Action PotentialsCalcium SignalingModels, NeurologicalAnimalsGanglia, SpinalImaging, Three-DimensionalIon ChannelsPatch-Clamp TechniquesSensory Receptor CellsIon Channels

Identifiers

PMID28592688
PMCPMC5558030

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.