ArticleJournal of neurophysiology2017
Efferent inhibition strength is a physiological correlate of hyperacusis in children with autism spectrum disorder.
Article in Journal of neurophysiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.
- Autism Spectrum Disorder and auditory sensory alterations: a systematic review on the integrity of cognitive and neuronal functions related to auditory processing.Journal of neural transmission (Vienna, Austria : 1996) · 2023Pooled it
- Otological conditions and autism spectrum disorder in Medicaid beneficiaries aged 1 to 20 years: a cross-sectional study.BMC pediatrics · 2026Article
- Hyperacusis in gifted children and its impact on quality of life.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2025Article
- Influence of Different Types of Contralateral Suppression Tones on Otoacoustic Emission in Children With Autism Spectrum Disorder.Journal of audiology & otology · 2025Article
- Alterations in KIDINS220/ARMS Expression Impact Sensory Processing and Social Behavior in Adult Mice.International journal of molecular sciences · 2024Article
- Auditory symptoms and autistic spectrum disorder: A scoping review and recommendations for future research.Journal of otology · 2022Article
- Family Experiences of Decreased Sound Tolerance in ASD.Journal of autism and developmental disorders · 2022Article
- Clinical and investigational tools for monitoring noise-induced hyperacusis.The Journal of the Acoustical Society of America · 2022Review
- Study on the Influence of Urban Built Environment Factors on the Social Behavior of ASD Children.Journal of environmental and public health · 2022Article
- Hyperacusis in Autism Spectrum Disorders.Audiology research · 2021Review
- [Hyperacusis: a mini review].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2021Review
- Medial olivocochlear reflex effects on amplitude growth functions of long- and short-latency components of click-evoked otoacoustic emissions in humans.Journal of neurophysiology · 2021Article
- A review of decreased sound tolerance in autism: Definitions, phenomenology, and potential mechanisms.Neuroscience and biobehavioral reviews · 2021Review
- A Time-Course-Based Estimation of the Human Medial Olivocochlear Reflex Function Using Clicks.Frontiers in neuroscience · 2021Article
- Article
- Measurements From Ears With Endolymphatic Hydrops and 2-Hydroxypropyl-Beta-Cyclodextrin Provide Evidence That Loudness Recruitment Can Have a Cochlear Origin.Frontiers in surgery · 2021Article
- Hyperacusis in children: a scoping review.BMC pediatrics · 2020Article
- Defining clusters of young autistic and typically developing children based on loudness-dependent auditory electrophysiological responses.Molecular autism · 2020Article
- Efficacy of Multi-Modal Migraine Prophylaxis Therapy on Hyperacusis Patients.The Annals of otology, rhinology, and laryngology · 2020Article
- Hyperacusis in Children with Attention Deficit Hyperactivity Disorder: A Preliminary Study.International journal of environmental research and public health · 2020Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Autism spectrum disorder (ASD) is a developmental disability that is poorly understood. ASD can influence communication, social interaction, and behavior. Children with ASD often have sensory hypersensitivities, including auditory hypersensitivity (hyperacusis). In adults with hyperacusis who are otherwise neurotypical, the medial olivocochlear (MOC) efferent reflex is stronger than usual. In children with ASD, the MOC reflex has been measured, but without also assessing hyperacusis. We assessed the MOC reflex in children with ASD by measuring the strength of MOC-induced inhibition of transient-evoked otoacoustic emissions (TEOAEs), a noninvasive physiological measure that reflects cochlear amplification. MOC activity was evoked by contralateral noise. Hyperacusis was assessed subjectively on the basis of the children's symptoms. We found a significant correlation between hyperacusis scores and MOC strength in children with ASD. When children were divided into ASD-with-severe-hyperacusis (ASDs), ASD-with-not-severe-hyperacusis (ASDns), and neurotypical (NT) groups, the last two groups had similar hyperacusis and MOC reflexes, whereas the ASDs group, on average, had hyperacusis and MOC reflexes that were approximately twice as strong. The MOC inhibition of TEOAEs averaged larger at all frequencies in the ASDs compared with ASDns and NT groups. The results suggest that the MOC reflex can be used to estimate hyperacusis in children with ASD and might be used to validate future questionnaires to assess hyperacusis. Our results also provide evidence that strong MOC reflexes in children with ASD are associated with hyperacusis and that hyperacusis is a comorbid condition and is not a necessary, integral part of the abnormal neural processing associated with ASD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.