ArticleJournal of neurophysiology2017
Robotic navigation to subcortical neural tissue for intracellular electrophysiology in vivo.
Article in Journal of neurophysiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 34 citations in OpenAlex.
- Patch-walking, a coordinated multi-pipette patch clamp for efficiently finding synaptic connections.eLife · 2024Article
- Patch-walking: Coordinated multi-pipette patch clamp for efficiently finding synaptic connections.bioRxiv : the preprint server for biology · 2024Article
- A biologically validated mathematical model for decoding epithelial apical, basolateral, and paracellular electrical properties.American journal of physiology. Cell physiology · 2023Article
- Electrophysiological and morphological characterization of single neurons in intact human brain organoids.Journal of neuroscience methods · 2023Article
- Robotic Intracellular Pressure Measurement Using Micropipette Electrode.Sensors (Basel, Switzerland) · 2023Article
- Inferring thalamocortical monosynaptic connectivity in vivo.Journal of neurophysiology · 2021Article
- Deep learning-based real-time detection of neurons in brain slices for in vitro physiology.Scientific reports · 2021Article
- In Vivo Whole-Cell Patch-Clamp Methods: Recent Technical Progress and Future Perspectives.Sensors (Basel, Switzerland) · 2021Review
- Automatic deep learning-driven label-free image-guided patch clamp system.Nature communications · 2021Article
- Compensation of physiological motion enables high-yield whole-cell recording in vivo.Journal of neuroscience methods · 2021Article
- Engineering microscale systems for fully autonomous intracellular neural interfaces.Microsystems & nanoengineering · 2020Article
- Autonomous patch-clamp robot for functional characterization of neurons in vivo: development and application to mouse visual cortex.Journal of neurophysiology · 2019Article
- Article
- Progress in automating patch clamp cellular physiology.Brain and neuroscience advancesReview
- Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
In vivo studies of neurophysiology using the whole cell patch-clamp technique enable exquisite access to both intracellular dynamics and cytosol of cells in the living brain but are underrepresented in deep subcortical nuclei because of fouling of the sensitive electrode tip. We have developed an autonomous method to navigate electrodes around obstacles such as blood vessels after identifying them as a source of contamination during regional pipette localization (RPL) in vivo. In mice, robotic navigation prevented fouling of the electrode tip, increasing RPL success probability 3 mm below the pial surface to 82% (
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.