ArticleClinical and vaccine immunology : CVI2017
Cytokines Are Markers of the Clostridium difficile-Induced Inflammatory Response and Predict Disease Severity.
Open access · diamondAbstract read
In one paragraph
Article in Clinical and vaccine immunology : CVI, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 89 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
89citing papers in PubMed, 1 pooled it
7.1field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
89 citing papers in PubMed, 1 synthesis or guideline pooled it, 115 citations in OpenAlex.
- Safety and efficacy of fecal microbiota transplantation for viral diseases: A systematic review of clinical trials.PloS one · 2024Pooled it
- Phenotypic profiling of neutrophils in acuteGut microbes · 2026Article
- Unveiling the Th17/Treg imbalance: a key player inGut microbes · 2026Article
- Balancing act of cytokines in controlling the severity ofInfection and immunity · 2026Review
- Phase variable colony morphotypes ofInfection and immunity · 2026Article
- The Gut Microbiome Dependency Continuum in Drug Discovery: A Unified Pharmacology Framework Linking Clinical Drugs, Natural Products, and Engineered Microbial Therapeutics.Biotech (Basel (Switzerland)) · 2026Review
- Article
- Modeling Clostridioides difficile toxin pathogenesis and antiserum protection in an immunocompetent intestine-on-chip platform.Scientific reports · 2026Article
- Phase variable colony morphotypes ofbioRxiv : the preprint server for biology · 2026Article
- High-fat diet rewires gut host-microbiota relationship to derive worse outcomes followingbioRxiv : the preprint server for biology · 2026Article
- Role of TLR4 in Enteric Glia Response to Clostridioides Difficile Toxins: Insights From In Vivo and In Vitro Studies.Journal of cellular and molecular medicine · 2025Article
- Pharmacological reduction of neutrophil infiltration reducesbioRxiv : the preprint server for biology · 2025Article
- Proinflammatory pathways contribute to the pathogenesis of Clostridioides difficile infection in a murine model using Spatial transcriptomics.Scientific reports · 2025Article
- Management ofEClinicalMedicine · 2025Review
- The interplay between host immunity andmBio · 2025Review
- The role of the enteric nervous system in the pathogenesis of Clostridioides difficile infection.Nature reviews. Gastroenterology & hepatology · 2025Review
- Inhibitory effects of Levilactobacillus brevis IBRC-M10790 on apoptosis and inflammation induced by Clostridioides difficile culture supernatant in vitro.Scientific reports · 2025Article
- Fiber- and acetate-mediated modulation of MHC-II expression on intestinal epithelium protects from Clostridioides difficile infection.Cell host & microbe · 2025Article
- ApoE COG 133 mimetic peptide improves survival, infection burden, andExperimental biology and medicine (Maywood, N.J.) · 2025Article
- Role of interleukin-16 in human diseases: a novel potential therapeutic target.Frontiers in immunology · 2025Review
29 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 5 institutions in 1 country.
Hua YuDepartment of Microbial Pathogenesis, University of Maryland Dental School, Baltimore, Maryland, USA.
Kevin ChenDepartment of Microbial Pathogenesis, University of Maryland Dental School, Baltimore, Maryland, USA.ORCID http://orcid.org/0000-0002-5120-6119
Ying SunDepartment of Microbial Pathogenesis, University of Maryland Dental School, Baltimore, Maryland, USA.
Mihaela CarterDepartment of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Kevin W GareyUniversity of Houston College of Pharmacy, Houston, Texas, USA.
Tor C SavidgeDepartment of Pathology and Immunology, Baylor College of Medicine, Houston, Texas, USA.
Sridevi DevarajDepartment of Pathology and Immunology, Baylor College of Medicine, Houston, Texas, USA.
Mary Elizabeth TessierDepartments of Pathology and Pediatrics, Texas Children's Hospital, Houston, Texas, USA.
Erik C von RosenvingeDivision of Gastroenterology & Hepatology, Department of Medicine, University of Maryland School of Medicine, and VA Maryland Health Care System, Baltimore, Maryland, USA.
Ciaran P KellyDepartment of Gastroenterology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA.
Marcela F PasettiDepartment of Pediatrics, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Hanping FengDepartment of Microbial Pathogenesis, University of Maryland Dental School, Baltimore, Maryland, USA hfeng@umaryland.edu.
University of Maryland, Baltimore · USBaylor College of Medicine · USBeth Israel Deaconess Medical Center · USTexas Children's Hospital · USUniversity of Houston · US
Funding
Tissue Analysis & Molecular Imaging CoreP30DK056338 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI James Versalovic · 2001 to 2026
$28.3MShigella Live Vector-Based Multivalent VaccineU19AI109776 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI LEVINE, MYRON MAX · 2014 to 2018
$25.4MDecoding Antibiotic-induced Susceptibility to Clostridium difficile InfectionU01AI124290 · NIAID · BAYLOR COLLEGE OF MEDICINE · PI BRITTON, ROBERT A, GAREY, KEVIN W · 2016 to 2020
$7.9MDevelopment of Vaccines against Clostridium difficile InfectionR01AI088748 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI FENG, HANPING, TZIPORI, SAUL R · 2010 to 2014
$3.1MAllosteric therapy of the Clostridium difficile toxinsR01AI100914 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI SAVIDGE, TOR C. · 2012 to 2016
$1.9MEpithelium, dendritic cells, and Clostridium difficile associated colitisR01DK084509 · NIDDK · UNIVERSITY OF MARYLAND BALTIMORE · PI FENG, HANPING · 2010 to 2014
$1.7MCombination Clostridium Difficile Toxin and Adhesin VaccineR01AI095256 · NIAID · AARON DIAMOND AIDS RESEARCH CENTER · PI HO, DAVID D, KELLY, CIARAN P · 2012 to 2015
$1.3MMetabolome-Based Biomarkers and Neutraceuticals in Clostridium Difficile InfectionR21DK096323 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI SAVIDGE, TOR C. · 2014 to 2015
$433kA Yeast based Immunotherapy against Clostridium difficile InfectionR43AI129044 · NIAID · FZATA, INC. · PI YANG, ZHIYONG · 2017 to 2017
$225kNIAID NIH HHS R01 AI088748NIAID NIH HHS R01 AI095256NIAID NIH HHS R01 AI100914NIAID NIH HHS R43 AI129044NIAID NIH HHS U01 AI124290NIAID NIH HHS U19 AI109776NIDDK NIH HHS P30 DK056338NIDDK NIH HHS R01 DK084509NIDDK NIH HHS R21 DK096323
Abstract
The host immune response affects pathogen virulence in
Indexed as
BiomarkersClostridioides difficileClostridium InfectionsCytokinesGlucosyltransferasesHumansInterferon-gammaInterleukin-17Interleukin-5Interleukin-6Interleukin-8PrognosisSeverity of Illness IndexBiomarkersCytokinesGlucosyltransferasesIL17A protein, humanIL5 protein, humanInterferon-gammaInterleukin-17Interleukin-5Interleukin-6Interleukin-8Clostridium difficile infectioncytokine responsedisease severityglucosyltransferase activity
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.