ArticleCirculation. Cardiovascular imaging2017
Right Heart End-Systolic Remodeling Index Strongly Predicts Outcomes in Pulmonary Arterial Hypertension: Comparison With Validated Models.
Open access · bronzeAbstract readComparative Study
In one paragraph
Article in Circulation. Cardiovascular imaging, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 4 of them syntheses that pooled it.
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49citing papers in PubMed, 4 pooled it
7.8field-weighted citation impact, top 2% of its field
What it found
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The trial behind it
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Who cites it
49 citing papers in PubMed, 4 syntheses or guidelines pooled it, 91 citations in OpenAlex.
- The predictive value of right ventricle speckle tracking echocardiography in patients undergoing cardiac surgery, a systematic review and meta-analysis.Cardiovascular ultrasound · 2025Pooled it
- Prognostic Value of Serial Risk Stratification in Adult and Pediatric Pulmonary Arterial Hypertension: A Systematic Review.Journal of the American Heart Association · 2024Pooled it
- Prognostic value of right ventricular free-wall longitudinal strain in patients with pulmonary hypertension: systematic review and meta-analyses.Open heart · 2024Pooled it
- Pooled it
- Effects of riociguat on right ventricular size and function in pulmonary arterial hypertension (RIVER II): a prospective, phase IV study.Respiratory research · 2026Trial
- Article
- Identification of RUNX1 as a Biomarker for Right Ventricular Remodeling in Pulmonary Arterial Hypertension Using WGCNA.Pulmonary circulation · 2026Article
- Biventricular dysfunction and blood oxygenation deficits in obstructive sleep apnea: a prospective study with non-contrast cardiac MRI.BMC medical imaging · 2026Article
- Transthoracic echocardiography of left ventricular underfilling improves risk stratification in pulmonary arterial hypertension.Scientific reports · 2025Article
- Assessment of right ventricular involvement in patients with anti-MDA5 Ab+ DM: a prospectively observational study with cardiac magnetic resonance imaging.Frontiers in cardiovascular medicine · 2025Article
- Impedance cardiography parameters reflecting left ventricular function are markers of pulmonary arterial hypertension.Frontiers in cardiovascular medicine · 2025Article
- Serum proteome profiling reveals HGFA as a candidate biomarker for pulmonary arterial hypertension.Respiratory research · 2024Article
- Pathophysiology of the right ventricle and its pulmonary vascular interaction.The European respiratory journal · 2024Review
- Risk stratification and treatment goals in pulmonary arterial hypertension.The European respiratory journal · 2024Review
- Tricuspid annular plane systolic excursion in pulmonary hypertension-Moving beyond the sector plane.Pulmonary circulation · 2024Article
- 3D Imaging Reveals Complex Microvascular Remodeling in the Right Ventricle in Pulmonary Hypertension.Circulation research · 2024Article
- Monitoring of the right ventricular responses to pressure overload: prognostic value and usefulness of echocardiography for clinical decision-making.Cardiovascular diagnosis and therapy · 2024Review
- Assessment of Right Ventricular Function-a State of the Art.Current heart failure reports · 2023Review
- Novel left ventricular mechanical index in pulmonary arterial hypertension.Pulmonary circulation · 2023Article
- Assessment and diagnosis of right ventricular failure-retrospection and future directions.Frontiers in cardiovascular medicine · 2023Review
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Authors and funding
13 authors at 1 institution in 1 country.
Myriam AmsallemFrom the Division of Cardiovascular Medicine (M.A., M.C.A., M.S., H.L., I.S., M.V.M., F.H.), Cardiovascular Institute (M.A., M.C.A., H.L., I.S., M.V.M., F.H.), Division of Pulmonary and Critical Care Medicine (A.J.S., R.T.Z.), Vera Moulton Wall Center at Stanford (M.R., R.T.Z., F.H.), and Division of Pediatrics (M.R.), Stanford University School of Medicine, CA; Research Unit Hypertension and Cardiovascular Epidemiology, KU Leuven Department of Cardiovascular Sciences, University of Leuven, Belgium (T.K.); and Division of Cardiothoracic Surgery, Marie Lannelongue Hospital, Le Plessis Robinson, France (O.M., E.F., M.A.). mamsallem@stanford.edu.
Andrew J SweattFrom the Division of Cardiovascular Medicine (M.A., M.C.A., M.S., H.L., I.S., M.V.M., F.H.), Cardiovascular Institute (M.A., M.C.A., H.L., I.S., M.V.M., F.H.), Division of Pulmonary and Critical Care Medicine (A.J.S., R.T.Z.), Vera Moulton Wall Center at Stanford (M.R., R.T.Z., F.H.), and Division of Pediatrics (M.R.), Stanford University School of Medicine, CA; Research Unit Hypertension and Cardiovascular Epidemiology, KU Leuven Department of Cardiovascular Sciences, University of Leuven, Belgium (T.K.); and Division of Cardiothoracic Surgery, Marie Lannelongue Hospital, Le Plessis Robinson, France (O.M., E.F., M.A.).
Marie C AymamiFrom the Division of Cardiovascular Medicine (M.A., M.C.A., M.S., H.L., I.S., M.V.M., F.H.), Cardiovascular Institute (M.A., M.C.A., H.L., I.S., M.V.M., F.H.), Division of Pulmonary and Critical Care Medicine (A.J.S., R.T.Z.), Vera Moulton Wall Center at Stanford (M.R., R.T.Z., F.H.), and Division of Pediatrics (M.R.), Stanford University School of Medicine, CA; Research Unit Hypertension and Cardiovascular Epidemiology, KU Leuven Department of Cardiovascular Sciences, University of Leuven, Belgium (T.K.); and Division of Cardiothoracic Surgery, Marie Lannelongue Hospital, Le Plessis Robinson, France (O.M., E.F., M.A.).
Tatiana KuznetsovaFrom the Division of Cardiovascular Medicine (M.A., M.C.A., M.S., H.L., I.S., M.V.M., F.H.), Cardiovascular Institute (M.A., M.C.A., H.L., I.S., M.V.M., F.H.), Division of Pulmonary and Critical Care Medicine (A.J.S., R.T.Z.), Vera Moulton Wall Center at Stanford (M.R., R.T.Z., F.H.), and Division of Pediatrics (M.R.), Stanford University School of Medicine, CA; Research Unit Hypertension and Cardiovascular Epidemiology, KU Leuven Department of Cardiovascular Sciences, University of Leuven, Belgium (T.K.); and Division of Cardiothoracic Surgery, Marie Lannelongue Hospital, Le Plessis Robinson, France (O.M., E.F., M.A.).
Mona SelejFrom the Division of Cardiovascular Medicine (M.A., M.C.A., M.S., H.L., I.S., M.V.M., F.H.), Cardiovascular Institute (M.A., M.C.A., H.L., I.S., M.V.M., F.H.), Division of Pulmonary and Critical Care Medicine (A.J.S., R.T.Z.), Vera Moulton Wall Center at Stanford (M.R., R.T.Z., F.H.), and Division of Pediatrics (M.R.), Stanford University School of Medicine, CA; Research Unit Hypertension and Cardiovascular Epidemiology, KU Leuven Department of Cardiovascular Sciences, University of Leuven, Belgium (T.K.); and Division of Cardiothoracic Surgery, Marie Lannelongue Hospital, Le Plessis Robinson, France (O.M., E.F., M.A.).
HongQuan LuFrom the Division of Cardiovascular Medicine (M.A., M.C.A., M.S., H.L., I.S., M.V.M., F.H.), Cardiovascular Institute (M.A., M.C.A., H.L., I.S., M.V.M., F.H.), Division of Pulmonary and Critical Care Medicine (A.J.S., R.T.Z.), Vera Moulton Wall Center at Stanford (M.R., R.T.Z., F.H.), and Division of Pediatrics (M.R.), Stanford University School of Medicine, CA; Research Unit Hypertension and Cardiovascular Epidemiology, KU Leuven Department of Cardiovascular Sciences, University of Leuven, Belgium (T.K.); and Division of Cardiothoracic Surgery, Marie Lannelongue Hospital, Le Plessis Robinson, France (O.M., E.F., M.A.).
Olaf MercierFrom the Division of Cardiovascular Medicine (M.A., M.C.A., M.S., H.L., I.S., M.V.M., F.H.), Cardiovascular Institute (M.A., M.C.A., H.L., I.S., M.V.M., F.H.), Division of Pulmonary and Critical Care Medicine (A.J.S., R.T.Z.), Vera Moulton Wall Center at Stanford (M.R., R.T.Z., F.H.), and Division of Pediatrics (M.R.), Stanford University School of Medicine, CA; Research Unit Hypertension and Cardiovascular Epidemiology, KU Leuven Department of Cardiovascular Sciences, University of Leuven, Belgium (T.K.); and Division of Cardiothoracic Surgery, Marie Lannelongue Hospital, Le Plessis Robinson, France (O.M., E.F., M.A.).
Elie FadelFrom the Division of Cardiovascular Medicine (M.A., M.C.A., M.S., H.L., I.S., M.V.M., F.H.), Cardiovascular Institute (M.A., M.C.A., H.L., I.S., M.V.M., F.H.), Division of Pulmonary and Critical Care Medicine (A.J.S., R.T.Z.), Vera Moulton Wall Center at Stanford (M.R., R.T.Z., F.H.), and Division of Pediatrics (M.R.), Stanford University School of Medicine, CA; Research Unit Hypertension and Cardiovascular Epidemiology, KU Leuven Department of Cardiovascular Sciences, University of Leuven, Belgium (T.K.); and Division of Cardiothoracic Surgery, Marie Lannelongue Hospital, Le Plessis Robinson, France (O.M., E.F., M.A.).
Ingela SchnittgerFrom the Division of Cardiovascular Medicine (M.A., M.C.A., M.S., H.L., I.S., M.V.M., F.H.), Cardiovascular Institute (M.A., M.C.A., H.L., I.S., M.V.M., F.H.), Division of Pulmonary and Critical Care Medicine (A.J.S., R.T.Z.), Vera Moulton Wall Center at Stanford (M.R., R.T.Z., F.H.), and Division of Pediatrics (M.R.), Stanford University School of Medicine, CA; Research Unit Hypertension and Cardiovascular Epidemiology, KU Leuven Department of Cardiovascular Sciences, University of Leuven, Belgium (T.K.); and Division of Cardiothoracic Surgery, Marie Lannelongue Hospital, Le Plessis Robinson, France (O.M., E.F., M.A.).
Michael V McConnellFrom the Division of Cardiovascular Medicine (M.A., M.C.A., M.S., H.L., I.S., M.V.M., F.H.), Cardiovascular Institute (M.A., M.C.A., H.L., I.S., M.V.M., F.H.), Division of Pulmonary and Critical Care Medicine (A.J.S., R.T.Z.), Vera Moulton Wall Center at Stanford (M.R., R.T.Z., F.H.), and Division of Pediatrics (M.R.), Stanford University School of Medicine, CA; Research Unit Hypertension and Cardiovascular Epidemiology, KU Leuven Department of Cardiovascular Sciences, University of Leuven, Belgium (T.K.); and Division of Cardiothoracic Surgery, Marie Lannelongue Hospital, Le Plessis Robinson, France (O.M., E.F., M.A.).
Marlene RabinovitchFrom the Division of Cardiovascular Medicine (M.A., M.C.A., M.S., H.L., I.S., M.V.M., F.H.), Cardiovascular Institute (M.A., M.C.A., H.L., I.S., M.V.M., F.H.), Division of Pulmonary and Critical Care Medicine (A.J.S., R.T.Z.), Vera Moulton Wall Center at Stanford (M.R., R.T.Z., F.H.), and Division of Pediatrics (M.R.), Stanford University School of Medicine, CA; Research Unit Hypertension and Cardiovascular Epidemiology, KU Leuven Department of Cardiovascular Sciences, University of Leuven, Belgium (T.K.); and Division of Cardiothoracic Surgery, Marie Lannelongue Hospital, Le Plessis Robinson, France (O.M., E.F., M.A.).
Roham T ZamanianFrom the Division of Cardiovascular Medicine (M.A., M.C.A., M.S., H.L., I.S., M.V.M., F.H.), Cardiovascular Institute (M.A., M.C.A., H.L., I.S., M.V.M., F.H.), Division of Pulmonary and Critical Care Medicine (A.J.S., R.T.Z.), Vera Moulton Wall Center at Stanford (M.R., R.T.Z., F.H.), and Division of Pediatrics (M.R.), Stanford University School of Medicine, CA; Research Unit Hypertension and Cardiovascular Epidemiology, KU Leuven Department of Cardiovascular Sciences, University of Leuven, Belgium (T.K.); and Division of Cardiothoracic Surgery, Marie Lannelongue Hospital, Le Plessis Robinson, France (O.M., E.F., M.A.).
Francois HaddadFrom the Division of Cardiovascular Medicine (M.A., M.C.A., M.S., H.L., I.S., M.V.M., F.H.), Cardiovascular Institute (M.A., M.C.A., H.L., I.S., M.V.M., F.H.), Division of Pulmonary and Critical Care Medicine (A.J.S., R.T.Z.), Vera Moulton Wall Center at Stanford (M.R., R.T.Z., F.H.), and Division of Pediatrics (M.R.), Stanford University School of Medicine, CA; Research Unit Hypertension and Cardiovascular Epidemiology, KU Leuven Department of Cardiovascular Sciences, University of Leuven, Belgium (T.K.); and Division of Cardiothoracic Surgery, Marie Lannelongue Hospital, Le Plessis Robinson, France (O.M., E.F., M.A.).
KU Leuven · BE
Funding
Pulmonary Hypertension Breakthrough InitiativeR24HL123767 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI ALDRED, MICHEALA A, ERZURUM, SERPIL C. · 2014 to 2017
$10.1MAirway redox biochemistry as a deteriminant of asthma phenotype during adolescen*U10HL109250 · NHLBI · UNIVERSITY OF VIRGINIA · PI ERZURUM, SERPIL C., GASTON, BENJAMIN · 2011 to 2016
$4.2MNHLBI NIH HHS R24 HL123767NHLBI NIH HHS U10 HL109250
Abstract
backgroundRight ventricular (RV) end-systolic dimensions provide information on both size and function. We investigated whether an internally scaled index of end-systolic dimension is incremental to well-validated prognostic scores in pulmonary arterial hypertension. METHODS AND
resultsFrom 2005 to 2014, 228 patients with pulmonary arterial hypertension were prospectively enrolled. RV end-systolic remodeling index (RVESRI) was defined by lateral length divided by septal height. The incremental values of RV free wall longitudinal strain and RVESRI to risk scores were determined. Mean age was 49±14 years, 78% were female, 33% had connective tissue disease, 52% were in New York Heart Association class ≥III, and mean pulmonary vascular resistance was 11.2±6.4 WU. RVESRI and right atrial area were strongly connected to the other right heart metrics. Three zones of adaptation (adapted, maladapted, and severely maladapted) were identified based on the RVESRI to RV systolic pressure relationship. During a mean follow-up of 3.9±2.4 years, the primary end point of death, transplant, or admission for heart failure was reached in 88 patients. RVESRI was incremental to risk prediction scores in pulmonary arterial hypertension, including the Registry to Evaluate Early and Long-Term PAH Disease Management score, the Pulmonary Hypertension Connection equation, and the Mayo Clinic model. Using multivariable analysis, New York Heart Association class III/IV, RVESRI, and log NT-proBNP (N-Terminal Pro-B-Type Natriuretic Peptide) were retained (χ
conclusionsRVESRI is a simple reproducible prognostic marker in patients with pulmonary arterial hypertension.
Indexed as
EchocardiographyStroke VolumeVentricular Function, RightVentricular RemodelingAdultCaliforniaCardiac CatheterizationCase-Control StudiesChi-Square DistributionFemaleHeart FailureHeart TransplantationHospitalizationHumansHypertension, PulmonaryHypertrophy, Right Ventricularechocardiographyheart failurepatient outcome assessmentpulmonary hypertensionright ventricular dysfunctionrisk assessmentventricular remodeling
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