ArticleBMJ open2017
Adverse childhood or adult experiences and risk of bilateral oophorectomy: a population-based case-control study.
Article in BMJ open, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Reproductive Health of Women Veterans: A Systematic Review of the Literature from 2008 to 2017.Seminars in reproductive medicine · 2018Pooled it
- The intersection of domestic abuse and menopause: a scoping review.BMC women's health · 2025Article
- Article
- Adverse childhood experiences increase the long-term accumulation of morbidity in women.Communications medicine · 2025Article
- Exposure to Adverse Childhood Experiences Predicts Increased Neurobehavioral Symptom Reporting in Adults with Mild Traumatic Brain Injury.Neurotrauma reports · 2024Article
- The Association of Adverse Childhood Experiences with Long-term Mood and Anxiety Disorders After Childhood Traumatic Brain Injury: A Population-based Case-Control Study.Archives of physical medicine and rehabilitation · 2023Article
- Women With a History of Primary Infertility and Increased Rates of Bilateral Oophorectomy.Obstetrics and gynecology · 2022Article
- Childhood adversity and gynecological conditions.Case reports in women's health · 2022Article
- Adverse childhood experiences are associated with increased risk of hysterectomy and bilateral oophorectomy: A national retrospective cohort study of women in England.BJOG : an international journal of obstetrics and gynaecology · 2022Article
- Premature or early bilateral oophorectomy: a 2021 update.Climacteric : the journal of the International Menopause Society · 2021Article
- Moving Beyond Reflexive and Prophylactic Gynecologic Surgery.Mayo Clinic proceedings · 2021Article
- Article
- Adverse childhood experiences are associated with increased risk of miscarriage in a national population-based cohort study in England.Human reproduction (Oxford, England) · 2020Article
- Mental health conditions diagnosed before bilateral oophorectomy: a population-based case-control study.Menopause (New York, N.Y.) · 2019Article
- Article
- Understanding the impact of sex and gender in Alzheimer's disease: A call to action.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2018Review
- Cohort profile: the Mayo Clinic Cohort Study of Oophorectomy and Aging-2 (MOA-2) in Olmsted County, Minnesota (USA).BMJ open · 2017Article
- Adverse Childhood Experiences and Increased Prevalence of Hysterectomy in a Nationally Representative U.S. Sample.Women's health reports (New Rochelle, N.Y.)Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
objectivesBilateral oophorectomy has commonly been performed in conjunction with hysterectomy even in women without a clear ovarian indication; however, oophorectomy may have long-term deleterious consequences. To better understand this surgical practice from the woman's perspective, we studied the possible association of adverse childhood or adult experiences with the subsequent occurrence of bilateral oophorectomy.
designPopulation-based case-control study.
settingOlmsted County, Minnesota (USA).
participantsFrom an established population-based cohort study, we sampled 128 women who underwent bilateral oophorectomy before age 46 years for a non-cancerous condition in 1988-2007 (cases) and 128 age-matched controls (±1 year).
methodsInformation about adverse experiences was abstracted from the medical records dating back to age 15 years or earlier archived in the Rochester Epidemiology Project (REP) records-linkage system. Adverse childhood experiences were summarised using the Adverse Childhood Experience (ACE) score.
resultsWe observed an association of bilateral oophorectomy performed before age 46 years with verbal or emotional abuse, physical abuse, any abuse, substance abuse in the household, and with an ACE score ≥1 experienced before age 19 years (OR=3.23; 95% CI 1.73 to 6.02; p<0.001). In women who underwent the oophorectomy before age 40 years, we also observed a strong association with physical abuse experienced during adulthood (OR=4.33; 95% CI 1.23 to 15.21; p=0.02). Several of the associations were higher in women who underwent oophorectomy at a younger age (<40 years) and in women without an ovarian indication for the surgery. None of the psychosocial or medical variables explored as potential confounders or intervening variables changed the results noticeably.
conclusionsWomen who suffered adverse childhood experiences or adult abuse are at increased risk of undergoing bilateral oophorectomy before menopause. We suggest that the association may be explained by a series of biological, emotional, and psychodynamic mechanisms.
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