Trial reportBMJ open2017
A cross-sectional study measuring vanadium and chromium levels in paediatric patients with CKD.
Trial report in BMJ open, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02126293 (Correction of Zinc Deficiency in Children With Chronic Kidney Disease and Kidney Transplant), which is not on this map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Correction of Zinc Deficiency in Children With Chronic Kidney Disease and Kidney Transplant
Who cites it
11 citing papers in PubMed, 23 citations in OpenAlex.
- Metal Pollution in the Air and Its Effects on Vulnerable Populations: A Narrative Review.International journal of molecular sciences · 2026Review
- Assessment and management of magnesium and trace element status in children with CKD stages 2-5, on dialysis and post-transplantation: Clinical practice points from the Pediatric Renal Nutrition Taskforce.Pediatric nephrology (Berlin, Germany) · 2025Review
- Vanadium toxicity and chronic kidney disease: implications in a green new world.Pediatric nephrology (Berlin, Germany) · 2025Article
- Vanadium exposure and kidney markers in a pediatric population: a cross-sectional study.Pediatric nephrology (Berlin, Germany) · 2025Article
- Prenatal metal exposures and kidney function in adolescence in Project Viva.Environmental health : a global access science source · 2024Article
- Associations among environmental exposure to trace elements and biomarkers of early kidney damage in the pediatric population.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2024Article
- Review
- Article
- The Effects of Chromium and Vanadium on Biomarkers of Carbohydrate and Lipid Metabolism in Workers Exposed to Coal Fly Ash.Journal of xenobiotics · 2022Article
- Co-Occurrence of Metal Contaminants in United States Public Water Systems in 2013-2015.International journal of environmental research and public health · 2021Article
- Chronic kidney disease of unknown aetiology in Sri Lanka and the exposure to environmental chemicals: a review of literature.Environmental geochemistry and health · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesAlthough many secondary effects of high levels of vanadium (V) and chromium (Cr) overlap with symptoms seen in paediatric patients with chronic kidney disease (CKD), their plasma V and Cr levels are understudied.
designAncillary cross-sectional study to a prospective, longitudinal, randomised controlled trial.
settingChildren's Hospital of Western Ontario, London Health Sciences Centre, London, Ontario, Canada.
participants36 children and adolescents 4-18 years of age with CKD.
interventions1-6 trace element measurements per patient. Cystatin C (CysC) estimated glomerular filtration rate (eGFR) was calculated using the Filler formula. Plasma V and Cr levels were measured using high-resolution sector field inductively coupled mass spectrometry. Anthropomorphic data and blood parameters were collected from our electronic chart programme. Water Cr and V data were obtained from the Ontario Water (Stream) Quality Monitoring Network. PRIMARY AND SECONDARY OUTCOME MEASURES: Primary outcomes: plasma Cr and V. SECONDARY OUTCOMES: age, season, CysC, CysC eGFR, and Cr and V levels in environmental water.
resultsThe median (IQR) eGFR was 51 mL/min/1.73 m
conclusionsOur study suggests that paediatric patients with CKD have elevated plasma levels of V and Cr. This may be the result of both environmental exposure and a low eGFR. It may be necessary to monitor V and Cr levels in patients with an eGFR <30 mL/min/1.73 m TRIAL REGISTRATION NUMBER: NCT02126293; HC#172241.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.