ArticleScience translational medicine2017
Ectopic calcification in pseudoxanthoma elasticum responds to inhibition of tissue-nonspecific alkaline phosphatase.
Abstract read
In one paragraph
Article in Science translational medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers.
0numbers the graph read from it
0cells of the map it votes in
77citing papers in PubMed
11.0field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
77 citing papers in PubMed, 108 citations in OpenAlex.
- Pilot study to evaluate the safety and effectiveness of etidronate treatment for arterial calcification due to deficiency of CD73 (ACDC).Vascular medicine (London, England) · 2024Trial
- Phase I studies of the safety, tolerability, pharmacokinetics, and pharmacodynamics of DS-1211, a tissue-nonspecific alkaline phosphatase inhibitor.Clinical and translational science · 2022Trial
- ABCC6 in Cellular Metabolic Homeostasis: Biochemical Links to Extracellular Nucleotide Signaling, Mitochondrial Stress, and Senescence.Cell biochemistry and biophysics · 2026Review
- The liver regulates ectopic calcification in Abcc6-deficient models of pseudoxanthoma elasticum.The Journal of clinical investigation · 2026Article
- ENPP1 inhibition as a therapeutic approach for later-onset hypophosphatasia.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2026Article
- Diabetes-induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice.FEBS open bio · 2026Article
- Article
- Multi-State Structural Genomics Enables Large-Scale, Mechanistic, and Context-Specific Classification of ABCC6 Genetic Variants Implicated in Calcification Diseases.International journal of molecular sciences · 2026Article
- Cell Calcification Models and Their Implications for Medicine and Biomaterial Research.Advanced healthcare materials · 2026Review
- Early-stage therapeutic efficacy of TNAP inhibition using a novel milder murine model of CKD-MBD.Experimental animals · 2026Article
- Liver-directed base editing ofMolecular therapy. Nucleic acids · 2025Article
- TNAP dephosphorylates phosphocholine and phosphoethanolamine and participates in triglyceride transport from the liver to the bloodstream.Communications biology · 2025Article
- Pharmacological targeting of the IL-17/neutrophil axis attenuates calcific deposits in rat models of calciphylaxis.The Journal of clinical investigation · 2025Article
- Rapamycin reduces mineral density and promotes beneficial vascular remodeling in a murine model of severe medial arterial calcification.American journal of physiology. Heart and circulatory physiology · 2025Article
- ABCC6 Involvement in Cerebral Small Vessel Disease: Potential Mechanisms and Associations.Genes · 2025Review
- Investigation on ABCC6-Deficient Human Hepatocytes Generated by CRISPR-Cas9 Genome Editing.Cells · 2025Article
- Rapamycin Reduces Mineral Density and Promotes Beneficial Vascular Remodeling in a Murine Model of Severe Medial Arterial Calcification.bioRxiv : the preprint server for biology · 2025Article
- Therapeutic approaches for the treatment of genetic and acquired cardiovascular calcification.Frontiers in cardiovascular medicine · 2025Review
- Bone Marrow-Derived ABCC6 Is an Essential Regulator of Ectopic Calcification In Pseudoxanthoma Elasticum.The Journal of investigative dermatology · 2024Article
- Gain-of-function mutations of TRPV4 acting in endothelial cells drive blood-CNS barrier breakdown and motor neuron degeneration in mice.Science translational medicine · 2024Article
17 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
13 authors at 7 institutions in 2 countries.
Shira G ZieglerInstitute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. sgziegler@jhmi.edu hdietz@jhmi.edu.ORCID 0000-0002-3007-9755
Carlos R FerreiraMedical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20814, USA.
Elena Gallo MacFarlaneInstitute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0001-5677-6842
Ryan C RiddleDepartment of Orthopaedic Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0001-7265-6939
Ryan E TomlinsonDepartment of Orthopaedic Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Emily Y ChewNational Eye Institute, National Institutes of Health, Bethesda, MD 20814, USA.ORCID 0000-0003-0999-9802
Ludovic MartinPXE Reference Center and MitoVasc Institute, Angers University Hospital, Angers, France.
Chen-Ting MaSanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA.
Eduard SergienkoSanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA.
Anthony B PinkertonSanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA.ORCID 0000-0003-4571-152X
José Luis MillánSanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA.
William A GahlMedical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20814, USA.ORCID 0000-0002-2494-6752
Harry C DietzInstitute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. sgziegler@jhmi.edu hdietz@jhmi.edu.ORCID 0000-0002-6856-0165
Sanford Burnham Prebys Medical Discovery Institute · USJohns Hopkins University · USNational Human Genome Research Institute · USHoward Hughes Medical Institute · USNational Institutes of Health · USUnited States Department of Veterans Affairs · USUniversité d'Angers · FR
Funding
Human Biochemical GeneticsZIAHG000215 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI GAHL, WILLIAM · 2009 to 2025
$72.6MMEDICAL SCIENTIST TRAINING PROGRAMT32GM007309 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI COX, ANDREA L · 1985 to 2019
$43.2MPredoctoral Training Program in Human GeneticsT32GM007814 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI VALLE, DAVID · 1985 to 2021
$10.6MMOLECULAR PATHOGENESIS/TREATMENT OF HYPOPHOSPHATASIAR01DE012889 · NIDCR · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI MILLAN, JOSE LUIS · 1999 to 2020
$9.2MMechanisms of initiation of skeletal mineralizationR01AR053102 · NIAMS · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI MILLAN, JOSE LUIS · 2006 to 2015
$3.8MZeiss LSM780 Confocal Microscope for a Core FacilityS10OD016374 · OD · JOHNS HOPKINS UNIVERSITY · PI KUO, SCOT CHARLES · 2013 to 2013
$584kHoward Hughes Medical InstituteNIAMS NIH HHS R01 AR053102NIDCR NIH HHS R01 DE012889NIGMS NIH HHS T32 GM007309NIGMS NIH HHS T32 GM007814NIH HHS S10 OD016374
Abstract
Biallelic mutations in
Indexed as
Adenosine TriphosphateAlkaline PhosphataseAnimalsATP-Binding Cassette, Sub-Family C ProteinsATP-Binding Cassette TransportersCalcinosisCrosses, GeneticDisease Models, AnimalEpistasis, GeneticExtracellular SpaceFemaleFibroblastsGene DeletionHumansLiverMaleABCC6 protein, humanAbcc6 protein, mouseAdenosine TriphosphateAlkaline PhosphataseALPL protein, mouseATP-Binding Cassette, Sub-Family C ProteinsATP-Binding Cassette Transportersectonucleotide pyrophosphatase phosphodiesterase 1Phosphoric Diester HydrolasesPyrophosphatases
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.