Evidence map›Paper›PMID 28592548›Full record

ArticleJournal of clinical microbiology2017

Evaluation of the Aptima HIV-1 Quant Dx Assay for HIV-1 RNA Quantitation in Different Biological Specimen Types.

Christina Yek, Marta Massanella, Tashi Peling, Kristen Lednovich, Sangeetha V Nair, Andrew Worlock, Milenka Vargas, Sara Gianella, Ronald J Ellis, Matthew C Strain and 3 more

Open access · bronzeAbstract readEvaluation Study
In one paragraph

Article in Journal of clinical microbiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 2 pooled it
1.3field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 2 syntheses or guidelines pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Article
  6. Everolimus, an mTORC1/2 inhibitor, in ART-suppressed individuals who received solid organ transplantation: A prospective study.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2021
    Article
  7. Article
  8. Performance evaluation of the Aptima HIV-1 RNA Quant assay on the Panther system using the standard and dilution protocols.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2020
    Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Christina YekUniversity of California San Diego, La Jolla, California, USA.
Marta MassanellaUniversity of California San Diego, La Jolla, California, USA.
Tashi PelingHologic Incorporated, San Diego, California, USA.
Kristen LednovichHologic Incorporated, San Diego, California, USA.
Sangeetha V NairHologic Incorporated, San Diego, California, USA.
Andrew WorlockHologic Incorporated, San Diego, California, USA.
Milenka VargasUniversity of California San Diego, La Jolla, California, USA.
Sara GianellaUniversity of California San Diego, La Jolla, California, USA.
Ronald J EllisUniversity of California San Diego, La Jolla, California, USA.
Matthew C StrainUniversity of California San Diego, La Jolla, California, USA.
Michael P BuschBlood Systems Research Institute, San Francisco, California, USA.
C Thomas NugentHologic Incorporated, San Diego, California, USA.
Douglas D RichmanUniversity of California San Diego, La Jolla, California, USA drichman@ucsd.edu.
University of California, San Diego · USHologic (United States) · USBlood Systems Research Institute · USVA San Diego Healthcare System · US

Funding

STRUCTURAL NEUROIMAGING COREP30MH062512 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DAVID J MOORE · 2001 to 2026
$50.4M
Using NK Cells to eliminate the latent HIV reservoirU19AI096113 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LUCIW, PAUL · 2011 to 2015
$39.5M
First-in-human study of two anti-SARS CoV-2 antibodies in health volunteersUM1AI126620 · NIAID · WISTAR INSTITUTE · PI MONTANER, LUIS J, RILEY, JAMES L. · 2016 to 2021
$24.5M
Collaboratory of AIDS Researchers for Eradication (CARE)UM1AI126619 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MARGOLIS, DAVID M. · 2016 to 2020
$23.2M
NIAID NIH HHS U19 AI096113NIAID NIH HHS UM1 AI126619
6 · The paper itself

Abstract

The search for a cure for HIV infection has highlighted the need for increasingly sensitive and precise assays to measure viral burden in various tissues and body fluids. We describe the application of a standardized assay for HIV-1 RNA in multiple specimen types. The fully automated Aptima HIV-1 Quant Dx assay (Aptima assay) is FDA cleared for blood plasma HIV-1 RNA quantitation. In this study, the Aptima assay was applied for the quantitation of HIV RNA in peripheral blood mononuclear cells (PBMCs;

Indexed as

Automation, LaboratoryHIV-1HumansRNA, ViralViral LoadRNA, Viralassay developmentcerebrospinal fluiddried blood spotsdried plasma spotshuman immunodeficiency virusperipheral blood mononuclear cellsplasmasemen

Identifiers

PMID28592548
PMCPMC5527433
OpenAlexW2623431847

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.