Evidence map›Paper›PMID 28592540›Full record

ArticleJournal of virology2017

Covalent Linkage of HIV-1 Trimers to Synthetic Liposomes Elicits Improved B Cell and Antibody Responses.

Shridhar Bale, Geraldine Goebrecht, Armando Stano, Richard Wilson, Takayuki Ota, Karen Tran, Jidnyasa Ingale, Michael B Zwick, Richard T Wyatt

Open access · bronzeAbstract read
In one paragraph

Article in Journal of virology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed
4.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 73 citations in OpenAlex.

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  11. Review
  12. Modulation of immune responses to liposomal vaccines by intrastructural help.European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V · 2023
    Article
  13. Article
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  16. Nanoparticles in clinical trials of COVID-19: An update.International journal of surgery (London, England) · 2022
    Review
  17. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Shridhar BaleDepartment of Immunology and Microbiology, Scripps Research Institute, La Jolla, California, USA.
Geraldine GoebrechtDepartment of Immunology and Microbiology, Scripps Research Institute, La Jolla, California, USA.
Armando StanoDepartment of Immunology and Microbiology, Scripps Research Institute, La Jolla, California, USA.
Richard WilsonInternational AIDS Vaccine Initiative, Neutralizing Antibody Center, Scripps Research Institute, La Jolla, California, USA.
Takayuki OtaDepartment of Immunology and Microbiology, Scripps Research Institute, La Jolla, California, USA.
Karen TranInternational AIDS Vaccine Initiative, Neutralizing Antibody Center, Scripps Research Institute, La Jolla, California, USA.
Jidnyasa IngaleDepartment of Immunology and Microbiology, Scripps Research Institute, La Jolla, California, USA.
Michael B ZwickDepartment of Immunology and Microbiology, Scripps Research Institute, La Jolla, California, USA.
Richard T WyattDepartment of Immunology and Microbiology, Scripps Research Institute, La Jolla, California, USA wyatt@scripps.edu.
Scripps Research Institute · USInternational AIDS Vaccine Initiative · US

Funding

Support Component D/Vaccine Discovery, Concept to ClinicUM1AI100663 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI BAROUCH, DAN H. · 2012 to 2018
$131.5M
MEDICAL SCIENTIST TRAINING PROGRAMT32GM007198 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHI, NEIL C, INSEL, PAUL A · 1985 to 2024
$29.3M
Non-Human PrimatesP01AI104722 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI WYATT, RICHARD THOMAS · 2014 to 2018
$14.6M
NIAID NIH HHS P01 AI104722NIAID NIH HHS UM1 AI100663NIGMS NIH HHS T32 GM007198
6 · The paper itself

Abstract

We have demonstrated that a liposomal array of well-ordered trimers enhances B cell activation, germinal center formation, and the elicitation of tier-2 autologous neutralizing antibodies. Previously, we coupled well-ordered cleavage-independent NFL trimers via their C-terminal polyhistidine tails to nickel lipids integrated into the lipid bilayer. Despite favorable

Indexed as

Antibody FormationAIDS VaccinesAnimalsB-LymphocytesDrug Carriersenv Gene Products, Human Immunodeficiency VirusEnzyme-Linked Immunosorbent AssayHistocytochemistryHIV AntibodiesLiposomesMice, Inbred C57BLAIDS VaccinesDrug Carriersenv Gene Products, Human Immunodeficiency VirusHIV AntibodiesLiposomesantibody repertoireHIV-1human immunodeficiency virusimmunizationimmunologyliposomesnanoparticlespathogensvaccines

Identifiers

PMID28592540
PMCPMC5533919
OpenAlexW2621975796

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.