ArticleGenetics2017
Genetic Dissection of Nutrition-Induced Plasticity in Insulin/Insulin-Like Growth Factor Signaling and Median Life Span in a
Article in Genetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed.
- Persistent effects of dietary selection and inbreeding on microbiome composition and longevity in Drosophila.BMC ecology and evolution · 2026Article
- Mapping of genotype-by-environment interaction loci for Metabolic Syndrome-like traits using the multi-parentbioRxiv : the preprint server for biology · 2025Article
- Interactive effects of developmental and adult nutrition on lifespan and fecundity in a genetically diverse Drosophila population.PloS one · 2025Article
- Gene model for the ortholog ofmicroPublication biology · 2025Article
- Misalignment of plastic and evolutionary responses of lifespan to novel carbohydrate diets.Royal Society open science · 2024Article
- Article
- Sex and tissue-specific evolution of developmental plasticity inEcology and evolution · 2021Article
- Transcriptome analysis of Aedes aegypti Aag2 cells in response to dengue virus-2 infection.Parasites & vectors · 2020Article
- Predicting longevity responses to dietary restriction: A stepping stone toward precision geroscience.PLoS genetics · 2020Article
- Genetic and metabolomic architecture of variation in diet restriction-mediated lifespan extension in Drosophila.PLoS genetics · 2020Article
- Diverse biological processes coordinate the transcriptional response to nutritional changes in a Drosophila melanogaster multiparent population.BMC genomics · 2020Article
- cis-regulatory variation modulates susceptibility to enteric infection in the Drosophila genetic reference panel.Genome biology · 2020Article
- Review
- Structural variants exhibit widespread allelic heterogeneity and shape variation in complex traits.Nature communications · 2019Article
- Multiple genetic loci affect place learning and memory performance in Drosophila melanogaster.Genes, brain, and behavior · 2019Article
- Testing PleiotropyG3 (Bethesda, Md.) · 2019Article
- Article
- Mitochondrial Dysfunction and Infection Generate Immunity-Fecundity Tradeoffs in Drosophila.Integrative and comparative biology · 2018Article
- Stress and early experience underlie dominance status and division of labour in a clonal insect.Proceedings. Biological sciences · 2018Article
- Horizons in the evolution of aging.BMC biology · 2018Review
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
The nutritional environments that organisms experience are inherently variable, requiring tight coordination of how resources are allocated to different functions relative to the total amount of resources available. A growing body of evidence supports the hypothesis that key endocrine pathways play a fundamental role in this coordination. In particular, the insulin/insulin-like growth factor signaling (IIS) and target of rapamycin (TOR) pathways have been implicated in nutrition-dependent changes in metabolism and nutrient allocation. However, little is known about the genetic basis of standing variation in IIS/TOR or how diet-dependent changes in expression in this pathway influence phenotypes related to resource allocation. To characterize natural genetic variation in the IIS/TOR pathway, we used >250 recombinant inbred lines (RILs) derived from a multiparental mapping population, the
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.