Evidence map›Paper›PMID 28592401›Full record

ArticleJournal of lipid research2017

Transgenic tomatoes expressing the 6F peptide and ezetimibe prevent diet-induced increases of IFN-β and cholesterol 25-hydroxylase in jejunum.

Pallavi Mukherjee, Greg Hough, Arnab Chattopadhyay, Mohamad Navab, Hannah R Fogelman, David Meriwether, Kevin Williams, Steven Bensinger, Travis Moller, Kym F Faull and 6 more

Open access · hybridFull text read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of lipid research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Implication of Oxysterols and Phytosterols in Aging and Human Diseases.Advances in experimental medicine and biology · 2024
    Review
  3. Article
  4. Review
  5. HDL Mimetic Peptides.Advances in experimental medicine and biology · 2022
    Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Oxysterols in intestinal immunity and inflammation.Journal of internal medicine · 2019
    Review
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 1 institution in 1 country.

Pallavi MukherjeeDepartments of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA.
Greg HoughDepartments of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA.
Arnab ChattopadhyayDepartments of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA.
Mohamad NavabDepartments of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA.
Hannah R FogelmanDepartments of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA.
David MeriwetherMolecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, CA.
Kevin WilliamsMolecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, CA.
Steven BensingerMolecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, CA.
Travis MollerSemel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine at UCLA, Los Angeles, CA.
Kym F FaullSemel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine at UCLA, Los Angeles, CA.
Aldons J LusisDepartments of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA; Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA; Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA.
M Luisa Iruela-ArispeDepartment of Molecular, Cell, and Developmental Biology, College of Letters and Sciences, University of California, Los Angeles, CA.
Kristina I BostromDepartments of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA.
Peter TontonozHoward Hughes Medical Institute, Los Angeles, CA; Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA.
Srinivasa T ReddyDepartments of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA; Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, CA; Obstetrics and Gynecology, David Geffen School of Medicine at UCLA, Los Angeles, CA. Electronic address: sreddy@mednet.ucla.edu.
Alan M FogelmanDepartments of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA.
University of California, Los Angeles · US

Funding

ULTRASTRUCTURE OF THE INTIMA IN EARLY LESION FORMATIONP01HL030568 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FOGELMAN, ALAN M · 1985 to 2019
$55.2M
Pilot and Feasibility ProgramP30DK041301 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ROZENGURT, JUAN ENRIQUE · 1990 to 2019
$18.0M
NHLBI NIH HHS P01 HL030568NIDDK NIH HHS P30 DK041301
6 · The paper itself

Abstract

Feeding LDL receptor (LDLR)-null mice a Western diet (WD) increased the expression of IFN-β in jejunum as determined by quantitative RT-PCR (RT-qPCR), immunohistochemistry (IHC), and ELISA (all

Indexed as

AnimalsDiet, WesternDuodenumDyslipidemiasEzetimibeGene ExpressionInterferon-alphaInterferon-betaJejunumMicePeptidesPlants, Genetically ModifiedRNA, MessengerSolanum lycopersicumSteroid Hydroxylases6F peptidecholesterol 25-hydroxylaseEzetimibeInterferon-alphaInterferon-betaPeptidesRNA, MessengerSteroid Hydroxylasesapolipoprotein A-I mimetic peptidesather­osclerosishyperlipidemiaoxysterols

Identifiers

PMID28592401
PMCPMC5538285
OpenAlexW2622329899

What OpenQuestion holds

Textfull text, public
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.