Evidence map›Paper›PMID 28592385›Full record

ArticleJournal of autoimmunity2017

Nucleotide-binding oligomerization domain-containing protein 2 (Nod2) modulates T1DM susceptibility by gut microbiota.

Yang-Yang Li, James A Pearson, Chen Chao, Jian Peng, Xiaojun Zhang, Zhiguang Zhou, Yu Liu, F Susan Wong, Li Wen

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of autoimmunity, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 28 citations in OpenAlex.

  1. Review
  2. Article
  3. Role and molecular mechanism of NOD2 in chronic non-communicable diseases.Journal of molecular medicine (Berlin, Germany) · 2024
    Review
  4. Article
  5. Article
  6. Article
  7. Host gene effects on gut microbiota in type 1 diabetes.Biochemical Society transactions · 2022
    Review
  8. Article
  9. Innate immunity in latent autoimmune diabetes in adults.Diabetes/metabolism research and reviews · 2022
    Review
  10. NOD-like receptors in autoimmune diseases.Acta pharmacologica Sinica · 2021
    Review
  11. Inflammasomes and Type 1 Diabetes.Frontiers in immunology · 2021
    Review
  12. Review
  13. Review
  14. Article
  15. Article
  16. Autoimmunity in 2017.Clinical reviews in allergy & immunology · 2018
    Review
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 3 countries.

Yang-Yang LiSection of Endocrinology, School of Medicine, Yale University, New Haven, CT, 06519, USA; Department of Endocrinology, The 2nd Hospital of Jilin University, Changchun, Jilin, 130041, China.
James A PearsonSection of Endocrinology, School of Medicine, Yale University, New Haven, CT, 06519, USA.
Chen ChaoSection of Endocrinology, School of Medicine, Yale University, New Haven, CT, 06519, USA; Key Laboratory of Diabetes Immunology, Department of Metabolism and Endocrinology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, 410011, China.
Jian PengSection of Endocrinology, School of Medicine, Yale University, New Haven, CT, 06519, USA.
Xiaojun ZhangSection of Endocrinology, School of Medicine, Yale University, New Haven, CT, 06519, USA.
Zhiguang ZhouKey Laboratory of Diabetes Immunology, Department of Metabolism and Endocrinology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, 410011, China.
Yu LiuDepartment of Endocrinology, The 2nd Hospital of Jilin University, Changchun, Jilin, 130041, China; Department of Endocrinology, Sir Run Run Shaw Hospital, Nanjing Medical University, Nanjing, Jiangsu, 211100, China.
F Susan WongDiabetes Research Group, Division of Infection and Immunity, School of Medicine, Cardiff University, Wales, CF14 4XN, UK.
Li WenSection of Endocrinology, School of Medicine, Yale University, New Haven, CT, 06519, USA; Key Laboratory of Diabetes Immunology, Department of Metabolism and Endocrinology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, 410011, China. Electronic address: li.wen@yale.edu.
Central South University · CNYale University · USJilin University · CNCardiff University · GB

Funding

Role of TLR9 in Beta Cell Function and DiabetesR01DK092882 · NIDDK · YALE UNIVERSITY · PI WEN, LI · 2012 to 2016
$1.8M
Dendritic cells in immuno-metabolic disorder in mouse and manR01DK100500 · NIDDK · YALE UNIVERSITY · PI WEN, LI · 2014 to 2017
$1.4M
NIDDK NIH HHS R01 DK092882NIDDK NIH HHS R01 DK100500
6 · The paper itself

Abstract

Nucleotide-binding oligomerization domain-containing protein 2 (Nod2) is an innate immune receptor. To investigate the role of Nod2 in susceptibility to the autoimmune disease, type 1 diabetes mellitus (T1DM), we generated Nod2

Indexed as

Disease SusceptibilityGastrointestinal MicrobiomeAnimalsB-LymphocytesCytokinesDendritic CellsDiabetes Mellitus, Type 1Disease Models, AnimalFemaleHumansImmunity, InnateImmunoglobulin A, SecretoryMacrophagesMice, Inbred NODMice, KnockoutNod2 Signaling Adaptor ProteinCytokinesImmunoglobulin A, SecretoryNod2 protein, mouseNod2 Signaling Adaptor ProteinGut microbiotaInnate immunityNODNod2Type 1 diabetes mellitus

Identifiers

PMID28592385
PMCPMC8284907
OpenAlexW2621239922

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.