ArticleBMC complementary and alternative medicine2017
Antibacterial and anticancer activities of acetone extracts from in vitro cultured lichen-forming fungi.
Article in BMC complementary and alternative medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Anticancer activity of himantormione B: a new depsidone from the Antarctic lichen Himantormia lugubris, in colorectal cancer.Genes & genomics · 2026Article
- Gas Chromatography-Mass Spectrometry Profiling of Volatile Metabolites Produced by SomeMolecules (Basel, Switzerland) · 2023Article
- Inhibition of Autophagy Increases Cell Death in HeLa Cells through Usnic Acid Isolated from Lichens.Plants (Basel, Switzerland) · 2023Article
- Phytochemical Analysis, Antioxidant, Antimicrobial, and Cytotoxic Activity of Different Extracts ofPlants (Basel, Switzerland) · 2022Article
- In vitro evaluation of lysozyme activity and antimicrobial effect of extracts from four Tunisian lichens: Diploschistes ocellatus, Flavoparmelia caperata, Squamarina cartilaginea and Xanthoria parietina.Archives of microbiology · 2021Article
- Lichens-A Potential Source for Nanoparticles Fabrication: A Review on Nanoparticles Biosynthesis and Their Prospective Applications.Journal of fungi (Basel, Switzerland) · 2021Review
- Characterization of Sunflower Oil Extracts from the LichenMetabolites · 2020Article
- Anticancer Potential of Lichens' Secondary Metabolites.Biomolecules · 2020Review
- Oxidative stress mediated by gyrophoric acid from the lichen Umbilicaria hirsuta affected apoptosis and stress/survival pathways in HeLa cells.BMC complementary and alternative medicine · 2019Article
- Anti-Cancer Activity of Lobaric Acid and Lobarstin Extracted from the Antarctic Lichen Stereocaulon alpnum.Molecules (Basel, Switzerland) · 2018Article
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6 authors.
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Abstract
backgroundLichens that were used in traditional medicine for ages produce numerous secondary metabolites, however our knowledge about biological activities of substances secreted by separated bionts is scarce. The main objectives of this study were to isolate and find optimal conditions for the growth of mycelia from three common lichen-forming fungi, i.e. Caloplaca pusilla, Protoparmeliopsis muralis and Xanthoria parietina and to evaluate antibacterial and antiproliferative activities of their acetone extracts.
methodsAgar disc diffusion and broth microdilution methods were used to test antimicrobial activity against six species of bacteria. MTT method, flow cytometry assay and DAPI staining were applied to test antiproliferative activity of selected extracts against MCF-7 (human breast adenocarcinoma), PC-3 (human prostate cancer) and HeLa (human cervix adenocarcinoma) cancer cells.
resultsP. muralis strongly inhibited the growth of Gram-positive bacteria, i.e. Bacillus subtilis, Enterococcus faecalis, Staphylococcus aureus and Staphylococcus epidermidis (MICs from 6.67 to 100.00 μg mL
conclusionWe showed that selected acetone extracts demonstrated a strong antimicrobial and anticancer effects that suggests that aposymbiotically cultured lichen-forming fungi can be a source of antibacterial and antiproliferative compounds.
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