ArticleHead & face medicine2017
Vertical bone regeneration using rhBMP-2 and VEGF.
Article in Head & face medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
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Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Peri-implant bone regeneration in pigs.International journal of implant dentistry · 2024Pooled it
- Effects of extended guided bone regeneration on the labial alveolar wall of adjacent teeth in the anterior maxilla: a retrospective cohort study.Head & face medicine · 2026Article
- The Impact of Implant Surface Modifications on the Osseointegration Process: An Overview.Cureus · 2025Review
- Reducing Healing Period with DDM/rhBMP-2 Grafting for Early Loading in Dental Implant Surgery.Tissue engineering and regenerative medicine · 2025Article
- The rational design, biofunctionalization and biological properties of orthopedic porous titanium implants: a review.Frontiers in bioengineering and biotechnology · 2025Review
- Gene expression analysis of cytokines and MMPs in melatonin and rhBMP-2 enhanced bone remodeling.World journal of orthopedics · 2024Article
- Article
- Histological and Immunohistochemical Analysis of the Effects of Topical Melatonin Treatment Associated with Collagen Sponge and rhBMP-2 Protein on Bone Remodeling.Biomolecules · 2022Article
- Bone Morphogenetic Protein as Bone Additive around Dental Implant and its Impact on Osseointegration: a Systematic Review.Journal of dentistry (Shiraz, Iran) · 2022Article
- Influence of Xenogeneic and Alloplastic Carriers for Bone Augmentation on Human Unrestricted Somatic Stem Cells.Materials (Basel, Switzerland) · 2022Article
- Impact of Frontier Development of Alveolar Bone Grafting on Orthodontic Tooth Movement.Frontiers in bioengineering and biotechnology · 2022Review
- Advances in Barrier Membranes for Guided Bone Regeneration Techniques.Frontiers in bioengineering and biotechnology · 2022Review
- Pre-Clinical Models in Implant Dentistry: Past, Present, Future.Biomedicines · 2021Review
- Animal models of vertical bone augmentation (Review).Experimental and therapeutic medicine · 2021Review
- Influence of different carrier materials on biphasic calcium phosphate induced bone regeneration.Clinical oral investigations · 2021Article
- Dental Pulp Stem Cells on Implant Surface: An In Vitro Study.BioMed research international · 2021Article
- Overexpression Effects of miR-424 and BMP2 on the Osteogenesis of Wharton's Jelly-Derived Stem Cells.BioMed research international · 2021Article
- Current and future trends in periodontal tissue engineering and bone regeneration.Plastic and aesthetic research · 2021Article
- Vertical Bone Gain after Sinus Lift Procedures with Beta-Tricalcium Phosphate and Simultaneous Implant Placement-A Cross-Sectional Study.Medicina (Kaunas, Lithuania) · 2020Article
- Coaxial nanofiber scaffold with super-active platelet lysate to accelerate the repair of bone defects.RSC advances · 2020Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSufficient vertical and lateral bone supply and a competent osteogenic healing process are prerequisities for the successful osseointegration of dental implants in the alveolar bone. Several techniques including autologous bone grafts and guided bone regeneration are applied to improve quality and quantity of bone at the implantation site. Depending on the amount of lacking bone one- or two-stage procedures are required. Vertical bone augmentation has proven to be a challenge particularly in terms of bone volume stability. This study focuses on the three dimensional vertical bone generation in a one stage procedure in vivo. Therefore, a collagenous disc-shaped scaffold (ICBM = Insoluble Collagenous Bone Matrix) containing rhBMP-2 (Bone Morphogenetic Protein-2) and/or VEGF (Vascular Endothelial Growth Factor) was applied around the coronal part of a dental implant during insertion. RhBMP-2 and VEGF released directly at the implantation site were assumed to induce the generation of new vertical bone around the implant.
methodsOne hundred eight titanium implants were inserted into the mandible and the tibia of 12 mini pigs. Four experimental groups were formed: Control group, ICBM, ICBM + BMP-2, and ICBM + BMP-2 + VEGF. After 1, 4 and 12 weeks the animals were sacrificed and bone generation was investigated histologically and histomorphometrically.
resultsAfter 12 weeks the combination of ICBM + rhBMP2 + VEGF showed significantly more bone volume density (BVD%), a higher vertical bone gain (VBG) and more vertical bone gain around the implant (PVBG) in comparison to the control group.
conclusionBy using collagenous disc-shaped matrices in combination with rhBMP-2 and VEGF vertical bone can be generated in a one stage procedure without donor site morbidity. The results of the presenting study suggest that the combination of rhBMP-2 and VEGF applied locally by using a collagenous carrier improves vertical bone generation in vivo. Further research is needed to establish whether this technique is applicable in clinical routines.
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